Reaction profile

The FDA adverse-event record for elevated mean corpuscular volume (mcv)

79 FDA adverse-event reports reference elevated mean corpuscular volume (mcv) (VeDDRA 2854). See the species, breeds, and drugs most associated with it below.

79
reports citing this reaction
21.5%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
79
Total Reports
17
Deaths
21.5%
Death Rate

Species Most Affected

Dog 54
Cat 23
Horse 2

Breeds Most Affected

Domestic Shorthair 12
Retriever - Labrador 7
Retriever - Golden 5
Shepherd Dog - Australian 4
Shih Tzu 2
Dachshund (unspecified) 2
Spaniel - King Charles Cavalier 2
American Shorthair 2
Collie - Border 2
Shepherd Dog - German 2

Associated Drugs

Maropitant Citrate 10
Afoxolaner 8
Lotilaner 8
Doxycycline 7
Milbemycin Oxime + Praziquantel 7
Gabapentin 7
Prednisone 7
Enrofloxacin 7
Milbemycin Oxime, Praziquantel 6
Eprinomectin + Esafoxolaner + Praziquantel 6
Fluralaner 13.64% 12-Week Chew 5
Dexamethasone 5
Famotidine 5
Buprenorphine 4
Fluralaner 4
Ondansetron 4
Pyrantel Pamoate;Sarolaner 4
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 4
Isoflurane 3
Melarsomine Dihydrochloride 3

Elevated mean corpuscular volume (MCV) Reaction Insights

79 reports name Elevated mean corpuscular volume (MCV); 17 recorded a death outcome (21.5% of reported events, not a population-level mortality rate). VeDDRA code: 2854.

By species: Dog (54 reports), Cat (23 reports), Horse (2 reports). By breed: Domestic Shorthair (12), Retriever - Labrador (7), Retriever - Golden (5).

Most co-reported drugs: Maropitant Citrate (10 reports), Afoxolaner (8 reports), Lotilaner (8 reports), Doxycycline (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.