Reaction profile

The FDA adverse-event record for painful defecation

106 FDA adverse-event reports reference painful defecation (VeDDRA 1983). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1362 of 2,481
by report volume (all reactions)
106
reports citing this reaction
19.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Painful defecation has 106 reports now versus 103 in that prior snapshot: 3 more (2.9%).

Report change
+3
Death-coded reports
+2
Death-coded share
+1.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Painful defecation changes

FDA AER · VeDDRA plate

Code 1983 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 106 reports
  • DEATH-ELEV 19.8%
  • MID-PACK #1362/2481
  • PHOTO-FINISH Contamination, Insects
  • SPECIES-DOG Dog · 85
  • DRUG-LEAD Milbemycin Oxime… · 13
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Contamination, Insects (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Painful defecation

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Contamination, Insects · near106Gall bladder inflamma… · near106Injection site pannic… · near106Painful defecation · this re…106Partial adipsia · near106Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Painful defecation

What the FDA AER plate says about Painful defecation

Signature read: death-coded share at 19.8% is the most distinctive outcome stamp on Painful defecation. Report volume sits in the middle third of the reaction corpus. 21 of 106 reports were death-coded (19.8% of named reports, not a population mortality rate). Nearest volume peer: Contamination, Insects (±0 reports). Lead species Dog (85). Lead co-reported drug Milbemycin Oxime + Spinosad (13).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 85
Cat 17
Cattle 2
Horse 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 10
Crossbred Canine/dog 7
Retriever - Golden 6
Shih Tzu 5
Chihuahua 5
Dog (unknown) 4
Domestic Mediumhair 4
Terrier - Boston 4
Terrier (unspecified) 4
Shepherd Dog - German 4

Associated Drugs

Milbemycin Oxime + Spinosad 13
Spinosad 7
Cyclosporine A 7
Grapiprant 7
Imidacloprid + Moxidectin 6
Carprofen 6
Cefovecin 6
Cyclosporine 5
Tramadol 5
Selamectin 5
Polysulfated Glycosaminoglycan 5
Gabapentin 5
Prednisone 4
Enrofloxacin 4
Fluralaner Chew Tablets 4
Dexmedetomidine Hydrochloride 3
Emodepside + Praziquantel 3
Maropitant Citrate 3
Famotidine 3
Ivermectin + Pyrantel As Pamoate Salt 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Painful defecation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (19.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Painful defecation (#1362 of 2,481 by report volume); death-coded 19.8%. PlainBreed reaction plate · death-coded share stamp 19.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →