Reaction profile

The FDA adverse-event record for elevated lipase

1,900 FDA adverse-event reports reference elevated lipase (VeDDRA 2168). See the species, breeds, and drugs most associated with it below.

1,900
reports citing this reaction
23.4%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,900
Total Reports
444
Deaths
23.4%
Death Rate

Species Most Affected

Dog 1,711
Cat 185
Horse 3
Human 1

Breeds Most Affected

Crossbred Canine/dog 150
Retriever - Labrador 142
Domestic Shorthair 121
Terrier - Yorkshire 117
Boxer (German Boxer) 93
Chihuahua 68
Retriever - Golden 57
Dachshund (unspecified) 53
Shih Tzu 45
Maltese 44

Associated Drugs

Trilostane 287
Carprofen 187
Maropitant Citrate 150
Afoxolaner 131
Oclacitinib Maleate 128
Milbemycin Oxime + Spinosad 125
Fluralaner Chew Tablets 123
Bedinvetmab 82
Grapiprant 69
Ivermectin + Pyrantel As Pamoate Salt 66
Gabapentin 65
Meloxicam 62
Moxidectin 56
Insulin Injectable Vial 56
Prednisone 55
Fluralaner 13.64% 12-Week Chew 53
Spinosad 52
Deracoxib 51
Tramadol 40
Cefovecin 40

Elevated lipase Reaction Insights

1,900 reports name Elevated lipase; 444 recorded a death outcome (23.4% of reported events, not a population-level mortality rate). VeDDRA code: 2168.

By species: Dog (1,711 reports), Cat (185 reports), Horse (3 reports). By breed: Crossbred Canine/dog (150), Retriever - Labrador (142), Domestic Shorthair (121).

Most co-reported drugs: Trilostane (287 reports), Carprofen (187 reports), Maropitant Citrate (150 reports), Afoxolaner (131 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.