Reaction profile

The FDA adverse-event record for lymphocytosis

1,027 FDA adverse-event reports reference lymphocytosis (VeDDRA 165). See the species, breeds, and drugs most associated with it below.

1,027
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,027
Total Reports
245
Deaths
23.9%
Death Rate

Species Most Affected

Dog 853
Cat 162
Horse 8
Cattle 2
Pig 2

Breeds Most Affected

Domestic Shorthair 109
Retriever - Labrador 95
Retriever - Golden 70
Crossbred Canine/dog 48
Shepherd Dog - German 35
Shih Tzu 34
Terrier - Yorkshire 32
Chihuahua 30
Spitz - German Pomeranian 22
Maltese 22

Associated Drugs

Milbemycin Oxime + Spinosad 123
Afoxolaner 103
Maropitant Citrate 90
Carprofen 72
Oclacitinib Maleate 72
Ivermectin + Pyrantel As Pamoate Salt 65
Cefovecin 51
Prednisone 41
Milbemycin Oxime + Praziquantel 39
Gabapentin 38
Pyrantel Pamoate;Sarolaner 35
Fluralaner Chew Tablets 34
Spinosad 33
Meloxicam 32
Bedinvetmab 32
Metronidazole 30
Moxidectin 30
Buprenorphine 30
Enrofloxacin 29
Lotilaner 26

Lymphocytosis Reaction Insights

1,027 reports name Lymphocytosis; 245 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 165.

By species: Dog (853 reports), Cat (162 reports), Horse (8 reports). By breed: Domestic Shorthair (109), Retriever - Labrador (95), Retriever - Golden (70).

Most co-reported drugs: Milbemycin Oxime + Spinosad (123 reports), Afoxolaner (103 reports), Maropitant Citrate (90 reports), Carprofen (72 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.