Reaction profile

The FDA adverse-event record for cardiac arrest

2,003 FDA reports name cardiac arrest, a high-volume reaction in the CVM extract (VeDDRA 195). Plate stamps and neighbourhood peers follow.

#232 of 2,481
by report volume (all reactions)
2,003
reports citing this reaction
83.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cardiac arrest has 2,003 reports now versus 1,985 in that prior snapshot: 18 more (0.9%).

Report change
+18
Death-coded reports
+14
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cardiac arrest changes

FDA AER · VeDDRA plate

Code 195 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,003 reports
  • DEATH-HOT 83.5%
  • TOP-DECILE #232/2481
  • PHOTO-FINISH Abnormal cytology
  • SPECIES-DOG Dog · 1,288
  • DRUG-LEAD Isoflurane · 318
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal cytology (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Cardiac arrest

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site prur… · near2009INEFFECTIVE, WHIPS · near2007Abnormal cytology · near2004Cardiac arrest · this reacti…2003Hind limb ataxia · near1999Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cardiac arrest

Cardiac arrest: high death-coded share in the FDA AER plate

Signature read: 1,672 death-coded reports is a heavy tail count for Cardiac arrest in the CVM extract. Report volume is upper-third scale: 2,003 named reports in the openFDA extract. Death-coded share is upper-third: 1,672 of 2,003 reports (83.5% of named reports). Nearest volume peer: Abnormal cytology (±1 reports). Lead species Dog (1,288). Lead co-reported drug Isoflurane (318).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,288
Cat 626
Rabbit 20
Other 19
Horse 9
Human 7
Guinea Pig 6
Cattle 4
Goat 3
Turtle 3

Breeds Most Affected

Domestic Shorthair 262
Domestic (unspecified) 122
Cat (unknown) 92
Chihuahua 87
Crossbred Canine/dog 81
Retriever - Labrador 79
Dog (unknown) 74
Unknown 63
Shih Tzu 61
Pug 58

Associated Drugs

Isoflurane 318
Dexmedetomidine Hydrochloride 306
Propofol 240
Maropitant Citrate 216
Butorphanol 180
Carprofen 160
Buprenorphine 135
Ketamine Hydrochloride 131
Butorphanol Tartrate 116
Ketamine 110
Atipamezole Hydrochloride 106
Dexmedetomidine 100
Epinephrine 97
Atropine 92
Cefovecin 79
Alfaxalone 76
Midazolam 73
Meloxicam 67
Sevoflurane 64
Moxidectin 63

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cardiac arrest, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,003 here).

Similar death-coded share

Nearest other reactions by death-coded share (83.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cardiac arrest (#232 of 2,481 by report volume); death-coded 83.5%. PlainBreed reaction plate · death-coded report count stamp 1,672 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →