Reaction profile

The FDA adverse-event record for hypokalaemia

1,980 FDA reports name hypokalaemia, a high-volume reaction in the CVM extract (VeDDRA 2418). Plate stamps and neighbourhood peers follow.

#236 of 2,481
by report volume (all reactions)
1,980
reports citing this reaction
28.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypokalaemia has 1,980 reports now versus 1,883 in that prior snapshot: 97 more (5.2%).

Report change
+97
Death-coded reports
+23
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypokalaemia changes

FDA AER · VeDDRA plate

Code 2418 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,980 reports
  • DEATH-HOT 28.7%
  • TOP-DECILE #236/2481
  • PHOTO-FINISH Elevated lipase
  • SPECIES-DOG Dog · 1,219
  • DRUG-LEAD Maropitant Citrate · 295
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated lipase (±4 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hypokalaemia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Mydriasis · near1997Elevated lipase · near1984Hypokalaemia · this reaction1980Circling - neurologic… · near1965Elevated symmetrical… · near1964Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypokalaemia

Hypokalaemia: high death-coded share in the FDA AER plate

Signature read: 568 death-coded reports is a heavy tail count for Hypokalaemia in the CVM extract. Report volume is upper-third scale: 1,980 named reports in the openFDA extract. Death-coded share is upper-third: 568 of 1,980 reports (28.7% of named reports). Nearest volume peer: Elevated lipase (±4 reports). Lead species Dog (1,219). Lead co-reported drug Maropitant Citrate (295).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,219
Cat 748
Horse 8
Human 3
Other Canids 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 531
Retriever - Labrador 125
Crossbred Canine/dog 86
Domestic Longhair 59
Retriever - Golden 58
Chihuahua 48
Domestic Mediumhair 43
Terrier - Yorkshire 38
Shih Tzu 38
Shepherd Dog - Australian 31

Associated Drugs

Maropitant Citrate 295
Velagliflozin Proline Monohydrate 198
Carprofen 176
Prednisone 169
Bexagliflozin 147
Gabapentin 107
Oclacitinib Maleate 106
Cefovecin 99
Trilostane 97
Afoxolaner 91
Buprenorphine 90
Moxidectin 79
Frunevetmab 72
Fluid Therapy 69
Ivermectin + Pyrantel As Pamoate Salt 67
Pyrantel Pamoate;Sarolaner 67
Desoxycortone Pivalate 66
Desoxycorticosterone Pivalate 63
Famotidine 60
Enrofloxacin 60

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hypokalaemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (28.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypokalaemia (#236 of 2,481 by report volume); death-coded 28.7%. PlainBreed reaction plate · death-coded report count stamp 568 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →