Reaction profile

The FDA adverse-event record for elevated pancreatic enzymes

279 FDA adverse-event reports reference elevated pancreatic enzymes (VeDDRA 2661). See the species, breeds, and drugs most associated with it below.

279
reports citing this reaction
22.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
279
Total Reports
62
Deaths
22.2%
Death Rate

Species Most Affected

Dog 240
Cat 39

Breeds Most Affected

Retriever - Labrador 23
Domestic Shorthair 20
Crossbred Canine/dog 18
Terrier - Yorkshire 15
Chihuahua 13
Boxer (German Boxer) 11
Retriever - Golden 10
Dog (unknown) 8
Terrier - Jack Russell 8
Beagle 7

Associated Drugs

Milbemycin Oxime + Spinosad 37
Bedinvetmab 28
Carprofen 27
Trilostane 27
Maropitant Citrate 25
Ivermectin + Pyrantel As Pamoate Salt 12
Deracoxib 11
Gabapentin 11
Pyrantel Pamoate;Sarolaner 10
Bexagliflozin 10
Afoxolaner 9
Prednisone 9
Enrofloxacin 9
Firocoxib 8
Grapiprant 8
Potassium Chloride 7
Unspecified Fluids 7
Meloxicam 6
Ampicillin 6
Famotidine 6

Elevated pancreatic enzymes Reaction Insights

279 reports name Elevated pancreatic enzymes; 62 recorded a death outcome (22.2% of reported events, not a population-level mortality rate). VeDDRA code: 2661.

By species: Dog (240 reports), Cat (39 reports). By breed: Retriever - Labrador (23), Domestic Shorthair (20), Crossbred Canine/dog (18).

Most co-reported drugs: Milbemycin Oxime + Spinosad (37 reports), Bedinvetmab (28 reports), Carprofen (27 reports), Trilostane (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.