Reaction profile

The FDA adverse-event record for elevated pancreatic enzymes

302 FDA adverse-event reports reference elevated pancreatic enzymes (VeDDRA 2661). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#864 of 2,481
by report volume (all reactions)
302
reports citing this reaction
22.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Elevated pancreatic enzymes has 302 reports now versus 294 in that prior snapshot: 8 more (2.7%).

Report change
+8
Death-coded reports
+1
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Elevated pancreatic enzymes changes

FDA AER · VeDDRA plate

Code 2661 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 302 reports
  • DEATH-HOT 22.5%
  • MID-PACK #864/2481
  • PHOTO-FINISH Injection site compli…
  • SPECIES-DOG Dog · 254
  • DRUG-LEAD Milbemycin Oxime… · 37
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Injection site complication NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Elevated pancreatic enzymes

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Elevated pancreatic e… · thi…302Injection site compli… · near302Lack of efficacy (ect… · near300Murmur · near300Swallowing difficult · near300Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Elevated pancreatic enzymes

What the FDA AER plate says about Elevated pancreatic enzymes

Signature read: 68 death-coded reports is a heavy tail count for Elevated pancreatic enzymes in the CVM extract. Report volume sits in the middle third of the reaction corpus. 68 of 302 reports were death-coded (22.5% of named reports, not a population mortality rate). Nearest volume peer: Injection site complication NOS (±0 reports). Lead species Dog (254). Lead co-reported drug Milbemycin Oxime + Spinosad (37).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 254
Cat 48

Breeds Most Affected

Domestic Shorthair 24
Retriever - Labrador 23
Crossbred Canine/dog 19
Terrier - Yorkshire 15
Chihuahua 13
Boxer (German Boxer) 13
Terrier - Jack Russell 10
Retriever - Golden 10
Dog (unknown) 8
Shih Tzu 7

Associated Drugs

Milbemycin Oxime + Spinosad 37
Bedinvetmab 31
Trilostane 30
Carprofen 28
Maropitant Citrate 28
Gabapentin 16
Bexagliflozin 15
Ivermectin + Pyrantel As Pamoate Salt 13
Deracoxib 11
Afoxolaner 10
Grapiprant 10
Enrofloxacin 10
Pyrantel Pamoate;Sarolaner 10
Prednisone 9
Firocoxib 8
Doxycycline 8
Unspecified Fluids 8
Ondansetron 8
Potassium Chloride 7
Buprenorphine 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Elevated pancreatic enzymes, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (22.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Elevated pancreatic enzymes (#864 of 2,481 by report volume); death-coded 22.5%. PlainBreed reaction plate · death-coded report count stamp 68 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →