Reaction profile

The FDA adverse-event record for bladder incontinence

282 FDA adverse-event reports reference bladder incontinence (VeDDRA 1346). See the species, breeds, and drugs most associated with it below.

282
reports citing this reaction
22.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
282
Total Reports
62
Deaths
22.0%
Death Rate

Species Most Affected

Dog 256
Cat 26

Breeds Most Affected

Retriever - Labrador 27
Crossbred Canine/dog 19
Boxer (German Boxer) 16
Domestic Shorthair 15
Retriever - Golden 14
Dog (unknown) 11
Shepherd Dog - German 9
Terrier - Yorkshire 8
Shepherd Dog - Australian 7
Maltese 7

Associated Drugs

Milbemycin Oxime + Spinosad 55
Afoxolaner 34
Bedinvetmab 26
Carprofen 18
Ivermectin + Pyrantel As Pamoate Salt 16
Milbemycin Oxime + Praziquantel 15
Sarolaner 13
Fluralaner Chew Tablets 13
Fluralaner 13.64% 12-Week Chew 11
Gabapentin 10
Lotilaner 10
Selamectin 9
Oclacitinib Maleate 9
Moxidectin 9
Pyrantel Pamoate;Sarolaner 9
Spinosad 8
Pimobendan 7
Buprenorphine 7
Ivermectin 6
Cefovecin 6

Bladder incontinence Reaction Insights

282 reports name Bladder incontinence; 62 recorded a death outcome (22.0% of reported events, not a population-level mortality rate). VeDDRA code: 1346.

By species: Dog (256 reports), Cat (26 reports). By breed: Retriever - Labrador (27), Crossbred Canine/dog (19), Boxer (German Boxer) (16).

Most co-reported drugs: Milbemycin Oxime + Spinosad (55 reports), Afoxolaner (34 reports), Bedinvetmab (26 reports), Carprofen (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.