Reaction profile

The FDA adverse-event record for elevated liver enzymes nos

717 FDA adverse-event reports reference elevated liver enzymes nos (VeDDRA 1942). See the species, breeds, and drugs most associated with it below.

717
reports citing this reaction
23.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
717
Total Reports
167
Deaths
23.3%
Death Rate

Species Most Affected

Dog 637
Cat 70
Horse 7
Human 2
Monkey 1

Breeds Most Affected

Retriever - Labrador 113
Crossbred Canine/dog 42
Domestic Shorthair 41
Dog (unknown) 36
Retriever - Golden 31
Terrier - Bull - American Pit 23
Shepherd Dog - German 21
Shih Tzu 20
Terrier (unspecified) 18
Chihuahua 17

Associated Drugs

Bedinvetmab 255
Carprofen 91
Gabapentin 73
Maropitant Citrate 59
Oclacitinib Maleate 56
Pyrantel Pamoate;Sarolaner 48
Moxidectin 34
Trilostane 30
Fluralaner 13.64% 12-Week Chew 28
Prednisone 27
Milbemycin Oxime + Praziquantel 24
Galliprant 24
Denamarin 23
Grapiprant 23
Afoxolaner 20
Doxycycline 19
Anti-Il31 Mab Mcs Lot #1283563 18
Enrofloxacin 16
Ondansetron 16
Frunevetmab 15

Elevated liver enzymes NOS Reaction Insights

717 reports name Elevated liver enzymes NOS; 167 recorded a death outcome (23.3% of reported events, not a population-level mortality rate). VeDDRA code: 1942.

By species: Dog (637 reports), Cat (70 reports), Horse (7 reports). By breed: Retriever - Labrador (113), Crossbred Canine/dog (42), Domestic Shorthair (41).

Most co-reported drugs: Bedinvetmab (255 reports), Carprofen (91 reports), Gabapentin (73 reports), Maropitant Citrate (59 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.