Reaction profile

The FDA adverse-event record for elevated liver enzymes nos

887 FDA reports name elevated liver enzymes nos, a high-volume reaction in the CVM extract (VeDDRA 1942). Plate stamps and neighbourhood peers follow.

#429 of 2,481
by report volume (all reactions)
887
reports citing this reaction
22.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Elevated liver enzymes NOS has 887 reports now versus 806 in that prior snapshot: 81 more (10.0%).

Report change
+81
Death-coded reports
+13
Death-coded share
−0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Elevated liver enzymes NOS changes

FDA AER · VeDDRA plate

Code 1942 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 887 reports
  • DEATH-HOT 22.5%
  • UPPER-Q #429/2481
  • PHOTO-FINISH Gall bladder & bile d…
  • SPECIES-DOG Dog · 784
  • DRUG-LEAD Bedinvetmab · 287
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gall bladder & bile duct disorder NOS (±4 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Elevated liver enzymes NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348INEFFECTIVE, WORMS NOS · near893Elevated liver enzyme… · thi…887Gall bladder & bile d… · near883Incoordination · near882Intestinal disorder N… · near881Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Elevated liver enzymes NOS

What the FDA AER plate says about Elevated liver enzymes NOS

Signature read: 200 death-coded reports is a heavy tail count for Elevated liver enzymes NOS in the CVM extract. Report volume is upper-third scale: 887 named reports in the openFDA extract. 200 of 887 reports were death-coded (22.5% of named reports, not a population mortality rate). Nearest volume peer: Gall bladder & bile duct disorder NOS (±4 reports). Lead species Dog (784). Lead co-reported drug Bedinvetmab (287).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 784
Cat 92
Horse 7
Human 3
Monkey 1

Breeds Most Affected

Retriever - Labrador 135
Domestic Shorthair 52
Crossbred Canine/dog 46
Dog (unknown) 43
Retriever - Golden 37
Chihuahua 26
Terrier (unspecified) 26
Shepherd Dog - German 25
Shih Tzu 25
Terrier - Bull - American Pit 24

Associated Drugs

Bedinvetmab 287
Carprofen 113
Gabapentin 86
Maropitant Citrate 77
Oclacitinib Maleate 74
Pyrantel Pamoate;Sarolaner 65
Moxidectin 53
Prednisone 40
Trilostane 37
Fluralaner 13.64% 12-Week Chew 32
Milbemycin Oxime + Praziquantel 31
Doxycycline 30
Grapiprant 26
Galliprant 24
Denamarin 24
Anti-Il31 Mab Mcs Lot #1283563 24
Ilunocitinib 24
Enrofloxacin 22
Afoxolaner 22
Ondansetron 21

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Elevated liver enzymes NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (22.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Elevated liver enzymes NOS (#429 of 2,481 by report volume); death-coded 22.5%. PlainBreed reaction plate · death-coded report count stamp 200 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →