Reaction profile

The FDA adverse-event record for elevated aspartate aminotransferase (ast)

2,378 FDA adverse-event reports reference elevated aspartate aminotransferase (ast) (VeDDRA 2049). See the species, breeds, and drugs most associated with it below.

2,378
reports citing this reaction
19.6%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
2,378
Total Reports
465
Deaths
19.6%
Death Rate

Species Most Affected

Dog 1,989
Cat 315
Horse 53
Cattle 9
Human 7
Sheep 1
Other 1
Other Rodents 1
Other Birds 1
Lynx 1

Breeds Most Affected

Retriever - Labrador 431
Domestic Shorthair 199
Crossbred Canine/dog 173
Retriever - Golden 74
Chihuahua 73
Shepherd Dog - German 49
Terrier - Yorkshire 46
Beagle 43
Shih Tzu 43
Maltese 41

Associated Drugs

Carprofen 607
Maropitant Citrate 167
Oclacitinib Maleate 154
Trilostane 145
Milbemycin Oxime + Spinosad 103
Afoxolaner 97
Fluralaner Chew Tablets 95
Gabapentin 86
Meloxicam 76
Moxidectin 68
Deracoxib 66
Spinosad 66
Ivermectin + Pyrantel As Pamoate Salt 63
Bedinvetmab 63
Tramadol 57
Famotidine 56
Sam-E, Silybin, Vitamin E, Zinc 52
Cefovecin 51
Prednisone 48
Fluralaner 13.64% 12-Week Chew 45

Elevated aspartate aminotransferase (AST) Reaction Insights

2,378 reports name Elevated aspartate aminotransferase (AST); 465 recorded a death outcome (19.6% of reported events, not a population-level mortality rate). VeDDRA code: 2049.

By species: Dog (1,989 reports), Cat (315 reports), Horse (53 reports). By breed: Retriever - Labrador (431), Domestic Shorthair (199), Crossbred Canine/dog (173).

Most co-reported drugs: Carprofen (607 reports), Maropitant Citrate (167 reports), Oclacitinib Maleate (154 reports), Trilostane (145 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.