Elevated aspartate aminotransferase (AST)
VeDDRA Code: 2049
2,378 adverse event reports referencing this reaction
2,378
Total Reports
465
Deaths
1960.0%
Death Rate
Species Most Affected
Dog 1,989
Cat 315
Horse 53
Cattle 9
Human 7
Sheep 1
Other 1
Other Rodents 1
Other Birds 1
Lynx 1
Breeds Most Affected
Retriever - Labrador 431
Domestic Shorthair 199
Crossbred Canine/dog 173
Retriever - Golden 74
Chihuahua 73
Shepherd Dog - German 49
Terrier - Yorkshire 46
Beagle 43
Shih Tzu 43
Maltese 41
Associated Drugs
Carprofen 607
Maropitant Citrate 167
Oclacitinib Maleate 154
Trilostane 145
Milbemycin Oxime + Spinosad 103
Afoxolaner 97
Fluralaner Chew Tablets 95
Gabapentin 86
Meloxicam 76
Moxidectin 68
Deracoxib 66
Spinosad 66
Ivermectin + Pyrantel As Pamoate Salt 63
Bedinvetmab 63
Tramadol 57
Famotidine 56
Sam-E, Silybin, Vitamin E, Zinc 52
Cefovecin 51
Prednisone 48
Fluralaner 13.64% 12-Week Chew 45
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.