Reaction profile

The FDA adverse-event record for haemorrhagic diarrhoea

640 FDA adverse-event reports reference haemorrhagic diarrhoea (VeDDRA 314). See the species, breeds, and drugs most associated with it below.

640
reports citing this reaction
17.5%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
640
Total Reports
112
Deaths
17.5%
Death Rate

Species Most Affected

Dog 612
Cat 24
Cattle 4

Breeds Most Affected

Retriever - Labrador 61
Crossbred Canine/dog 34
Terrier - Yorkshire 29
Shepherd Dog - German 26
Terrier - Bull - American Pit 23
Boxer (German Boxer) 20
Chihuahua 19
Shih Tzu 18
Dog (unknown) 17
Beagle 17

Associated Drugs

Moxidectin 74
Carprofen 71
Maropitant Citrate 46
Ivermectin + Pyrantel As Pamoate Salt 46
Afoxolaner 40
Trilostane 38
Imidacloprid + Moxidectin 33
Milbemycin Oxime + Spinosad 33
Metronidazole 31
Meloxicam 29
Melarsomine Dihydrochloride 27
Oclacitinib Maleate 25
Isoflurane 20
Diphenhydramine Hcl 20
Gabapentin 19
Grapiprant 18
Febantel + Praziquantel + Pyrantel Pamoate 15
Propofol 15
Pyrantel Pamoate;Sarolaner 15
Melarsomine Dihydrochloride Injection 14

Haemorrhagic diarrhoea Reaction Insights

640 reports name Haemorrhagic diarrhoea; 112 recorded a death outcome (17.5% of reported events, not a population-level mortality rate). VeDDRA code: 314.

By species: Dog (612 reports), Cat (24 reports), Cattle (4 reports). By breed: Retriever - Labrador (61), Crossbred Canine/dog (34), Terrier - Yorkshire (29).

Most co-reported drugs: Moxidectin (74 reports), Carprofen (71 reports), Maropitant Citrate (46 reports), Ivermectin + Pyrantel As Pamoate Salt (46 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.