Reaction profile

The FDA adverse-event record for disoriented state

641 FDA adverse-event reports reference disoriented state (VeDDRA 1418). See the species, breeds, and drugs most associated with it below.

641
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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641
Total Reports
84
Deaths
13.1%
Death Rate

Species Most Affected

Dog 527
Cat 91
Human 14
Horse 5
Cattle 3
Sheep 1

Breeds Most Affected

Domestic Shorthair 53
Crossbred Canine/dog 42
Retriever - Labrador 39
Retriever - Golden 34
Chihuahua 26
Terrier - Yorkshire 26
Shepherd Dog - German 24
Boxer (German Boxer) 18
Collie - Border 17
Shih Tzu 17

Associated Drugs

Milbemycin Oxime + Spinosad 107
Afoxolaner 55
Bedinvetmab 39
Fluralaner Chew Tablets 38
Pyrantel Pamoate;Sarolaner 35
Fluralaner 13.64% 12-Week Chew 28
Milbemycin Oxime + Praziquantel 27
Spinosad 24
Ivermectin + Pyrantel As Pamoate Salt 23
Buprenorphine 22
Carprofen 20
Imidacloprid + Moxidectin 19
Grapiprant 19
Maropitant Citrate 15
Sarolaner 15
Trilostane 15
Gabapentin 15
Meloxicam 14
Oclacitinib Maleate 14
Fluralaner Spot-On Solution 14

Disoriented state Reaction Insights

641 reports name Disoriented state; 84 recorded a death outcome (13.1% of reported events, not a population-level mortality rate). VeDDRA code: 1418.

By species: Dog (527 reports), Cat (91 reports), Human (14 reports). By breed: Domestic Shorthair (53), Crossbred Canine/dog (42), Retriever - Labrador (39).

Most co-reported drugs: Milbemycin Oxime + Spinosad (107 reports), Afoxolaner (55 reports), Bedinvetmab (39 reports), Fluralaner Chew Tablets (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.