Reaction profile

The FDA adverse-event record for disoriented state

666 FDA reports name disoriented state, a high-volume reaction in the CVM extract (VeDDRA 1418). Plate stamps and neighbourhood peers follow.

#534 of 2,481
by report volume (all reactions)
666
reports citing this reaction
13.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Disoriented state has 666 reports now versus 656 in that prior snapshot: 10 more (1.5%).

Report change
+10
Death-coded reports
+2
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Disoriented state changes

FDA AER · VeDDRA plate

Code 1418 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 666 reports
  • DEATH-ELEV 13.5%
  • UPPER-Q #534/2481
  • PHOTO-FINISH Difficulty to rise
  • SPECIES-DOG Dog · 539
  • DRUG-LEAD Milbemycin Oxime… · 107
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Difficulty to rise (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Disoriented state

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (pro… · near670Sedation prolonged · near670Urine leakage · near668Disoriented state · this rea…666Difficulty to rise · near665Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Disoriented state

What the FDA AER plate says about Disoriented state

Signature read: 90 death-coded reports is a heavy tail count for Disoriented state in the CVM extract. Report volume is upper-third scale: 666 named reports in the openFDA extract. 90 of 666 reports were death-coded (13.5% of named reports, not a population mortality rate). Nearest volume peer: Difficulty to rise (±1 reports). Lead species Dog (539). Lead co-reported drug Milbemycin Oxime + Spinosad (107).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 539
Cat 103
Human 14
Horse 5
Cattle 4
Sheep 1

Breeds Most Affected

Domestic Shorthair 64
Crossbred Canine/dog 44
Retriever - Labrador 40
Retriever - Golden 34
Chihuahua 27
Terrier - Yorkshire 26
Shepherd Dog - German 24
Boxer (German Boxer) 18
Shepherd Dog - Australian 17
Collie - Border 17

Associated Drugs

Milbemycin Oxime + Spinosad 107
Afoxolaner 58
Bedinvetmab 39
Fluralaner Chew Tablets 38
Pyrantel Pamoate;Sarolaner 38
Fluralaner 13.64% 12-Week Chew 29
Buprenorphine 27
Milbemycin Oxime + Praziquantel 27
Spinosad 24
Ivermectin + Pyrantel As Pamoate Salt 23
Carprofen 20
Imidacloprid + Moxidectin 19
Grapiprant 19
Robenacoxib 17
Gabapentin 16
Isoflurane 15
Maropitant Citrate 15
Sarolaner 15
Trilostane 15
Meloxicam 14

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Disoriented state, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (666 here).

Similar death-coded share

Nearest other reactions by death-coded share (13.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Disoriented state (#534 of 2,481 by report volume); death-coded 13.5%. PlainBreed reaction plate · death-coded report count stamp 90 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →