Reaction profile

The FDA adverse-event record for urine leakage

632 FDA adverse-event reports reference urine leakage (VeDDRA 2127). See the species, breeds, and drugs most associated with it below.

632
reports citing this reaction
10.8%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
632
Total Reports
68
Deaths
10.8%
Death Rate

Species Most Affected

Dog 577
Cat 49
Unknown 3
Horse 2
Cattle 1

Breeds Most Affected

Retriever - Labrador 79
Crossbred Canine/dog 40
Domestic Shorthair 38
Shepherd Dog - German 37
Boxer (German Boxer) 22
Retriever - Golden 21
Shepherd Dog - Australian 19
Dog (unknown) 17
Siberian Husky 16
Chihuahua 15

Associated Drugs

Bedinvetmab 117
Trilostane 79
Gabapentin 55
Milbemycin Oxime + Spinosad 52
Carprofen 51
Oclacitinib Maleate 32
Afoxolaner 31
Prednisone 29
Pyrantel Pamoate;Sarolaner 29
Maropitant Citrate 21
Milbemycin Oxime + Praziquantel 21
Fluralaner Chew Tablets 19
Ivermectin + Pyrantel As Pamoate Salt 18
Grapiprant 18
Fluralaner 13.64% 12-Week Chew 15
Tramadol 14
Desoxycorticosterone Pivalate 14
Lotilaner 14
Galliprant 14
Spinosad 13

Urine leakage Reaction Insights

632 reports name Urine leakage; 68 recorded a death outcome (10.8% of reported events, not a population-level mortality rate). VeDDRA code: 2127.

By species: Dog (577 reports), Cat (49 reports), Unknown (3 reports). By breed: Retriever - Labrador (79), Crossbred Canine/dog (40), Domestic Shorthair (38).

Most co-reported drugs: Bedinvetmab (117 reports), Trilostane (79 reports), Gabapentin (55 reports), Milbemycin Oxime + Spinosad (52 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.