Reaction profile

The FDA adverse-event record for elevated mean corpuscular haemoglobin concentration (mchc)

57 FDA adverse-event reports reference elevated mean corpuscular haemoglobin concentration (mchc) (VeDDRA 3091). See the species, breeds, and drugs most associated with it below.

57
reports citing this reaction
17.5%
death-coded share
Dog
most-affected species
Gabapentin
most-associated drug
Verify with FDA CVM →
57
Total Reports
10
Deaths
17.5%
Death Rate

Species Most Affected

Dog 41
Cat 16

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 8
Retriever - Golden 4
Dog (unknown) 2
Collie - Border 2
Domestic Longhair 2
Cat (unknown) 2
Terrier - Yorkshire 2
Persian 2
Whippet 2

Associated Drugs

Gabapentin 12
Carprofen 11
Maropitant Citrate 8
Prednisone 6
Sucralfate 5
Afoxolaner 5
Bexagliflozin 4
Enrofloxacin 4
Maropitant 4
Capromorelin 4
Metronidazole 4
Eprinomectin + Esafoxolaner + Praziquantel 4
Bedinvetmab 4
Milbemycin Oxime + Praziquantel 4
Lotilaner 4
Doxycycline 3
Balanced Electrolyte Solution 3
Amoxicillin 3
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 3
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 3

Elevated mean corpuscular haemoglobin concentration (MCHC) Reaction Insights

57 reports name Elevated mean corpuscular haemoglobin concentration (MCHC); 10 recorded a death outcome (17.5% of reported events, not a population-level mortality rate). VeDDRA code: 3091.

By species: Dog (41 reports), Cat (16 reports). By breed: Domestic Shorthair (10), Retriever - Labrador (8), Retriever - Golden (4).

Most co-reported drugs: Gabapentin (12 reports), Carprofen (11 reports), Maropitant Citrate (8 reports), Prednisone (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.