Reaction profile

The FDA adverse-event record for poor coat condition

216 FDA adverse-event reports reference poor coat condition (VeDDRA 1996). See the species, breeds, and drugs most associated with it below.

216
reports citing this reaction
9.7%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
216
Total Reports
21
Deaths
9.7%
Death Rate

Species Most Affected

Dog 131
Cat 40
Cattle 37
Horse 6
Bison 1
Other Equids 1

Breeds Most Affected

Domestic Shorthair 22
Retriever - Labrador 15
Shepherd Dog - German 12
Retriever - Golden 9
Holstein-Friesian also known as Holstein 7
Aberdeen Angus 7
Cattle (other) 7
Crossbred Canine/dog 7
Domestic Longhair 6
Crossbred Bovine/Cattle 6

Associated Drugs

Trilostane 58
Milbemycin Oxime + Spinosad 22
Eprinomectin 5% Injection 11
Afoxolaner 11
Prednisone 9
Fluralaner Chew Tablets 9
Moxidectin 8
Bexagliflozin 8
Spinosad 7
Buprenorphine 6
Ivermectin 6
Levothyroxine Sodium 6
Maropitant Citrate 6
Gabapentin 6
Selamectin 5
Carprofen 5
Eprinomectin 5 Mg/Ml Pour-On Solution 5
Merial La Polypropylene Syringe 5
Doxycycline 5
Portech App Gun 65 Ml Ivomec/Eprinex 5

Poor coat condition Reaction Insights

216 reports name Poor coat condition; 21 recorded a death outcome (9.7% of reported events, not a population-level mortality rate). VeDDRA code: 1996.

By species: Dog (131 reports), Cat (40 reports), Cattle (37 reports). By breed: Domestic Shorthair (22), Retriever - Labrador (15), Shepherd Dog - German (12).

Most co-reported drugs: Trilostane (58 reports), Milbemycin Oxime + Spinosad (22 reports), Eprinomectin 5% Injection (11 reports), Afoxolaner (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.