Reaction profile

The FDA adverse-event record for gingivitis

259 FDA adverse-event reports reference gingivitis (VeDDRA 286). See the species, breeds, and drugs most associated with it below.

259
reports citing this reaction
10.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
259
Total Reports
27
Deaths
10.4%
Death Rate

Species Most Affected

Dog 166
Cat 79
Horse 14

Breeds Most Affected

Domestic Shorthair 54
Crossbred Canine/dog 17
Retriever - Labrador 14
Chihuahua 9
Dachshund (unspecified) 7
Shih Tzu 7
Domestic Mediumhair 7
Maltese 6
Shepherd Dog - German 5
Siamese 5

Associated Drugs

Milbemycin Oxime + Spinosad 29
Trilostane 24
Rabies Vaccine 20
Cyclosporine 18
Unspecified 17
Maropitant Citrate 16
Milbemycin Oxime + Praziquantel 16
Spinosad 14
Cyclosporine A 14
Gabapentin 13
Selamectin 12
Imidacloprid + Moxidectin 11
Carprofen 10
Robenacoxib 10
Bexagliflozin 10
Bordetella Vaccine 9
Nitenpyram 9
Afoxolaner 9
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 8
Oclacitinib Maleate 8

Gingivitis Reaction Insights

259 reports name Gingivitis; 27 recorded a death outcome (10.4% of reported events, not a population-level mortality rate). VeDDRA code: 286.

By species: Dog (166 reports), Cat (79 reports), Horse (14 reports). By breed: Domestic Shorthair (54), Crossbred Canine/dog (17), Retriever - Labrador (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (29 reports), Trilostane (24 reports), Rabies Vaccine (20 reports), Cyclosporine (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.