Reaction profile

The FDA adverse-event record for difficulty chewing

95 FDA adverse-event reports reference difficulty chewing (VeDDRA 2450). See the species, breeds, and drugs most associated with it below.

95
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
95
Total Reports
7
Deaths
7.4%
Death Rate

Species Most Affected

Dog 67
Cat 19
Horse 8
Mule 1

Breeds Most Affected

Domestic Shorthair 15
Retriever - Labrador 9
Chihuahua 4
Crossbred Canine/dog 4
Collie - Border 4
Retriever - Golden 4
Terrier (unspecified) 2
Terrier - Boston 2
Quarter Horse 2
Pit Bull 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 15
Maropitant Citrate 11
Prednisone 8
Trilostane 8
Ivermectin + Pyrantel As Pamoate Salt 6
Gabapentin 6
Oclacitinib Maleate 5
Milbemycin Oxime + Praziquantel 5
Carprofen 5
Afoxolaner 4
Marbofloxacin 4
Anti-Il31 Mab Mcs Lot #1283563 4
Ivermectin + Praziquantel 4
Cyclosporine 4
Doxycycline 4
Lotilaner 4
Enrofloxacin 3
Fluids 3
Mirtazapine 3
Butorphanol 3

Difficulty chewing Reaction Insights

95 reports name Difficulty chewing; 7 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). VeDDRA code: 2450.

By species: Dog (67 reports), Cat (19 reports), Horse (8 reports). By breed: Domestic Shorthair (15), Retriever - Labrador (9), Chihuahua (4).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (15 reports), Maropitant Citrate (11 reports), Prednisone (8 reports), Trilostane (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.