Reaction profile

The FDA adverse-event record for hypochloraemia

1,640 FDA adverse-event reports reference hypochloraemia (VeDDRA 2578). See the species, breeds, and drugs most associated with it below.

1,640
reports citing this reaction
29.0%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,640
Total Reports
476
Deaths
29.0%
Death Rate

Species Most Affected

Dog 1,212
Cat 392
Horse 33
Cattle 2
Goat 1

Breeds Most Affected

Domestic Shorthair 247
Retriever - Labrador 101
Crossbred Canine/dog 75
Chihuahua 74
Maltese 49
Terrier - Yorkshire 43
Shih Tzu 43
Terrier - Boston 41
Beagle 33
Retriever - Golden 32

Associated Drugs

Trilostane 418
Maropitant Citrate 158
Velagliflozin Proline Monohydrate 123
Carprofen 118
Prednisone 92
Afoxolaner 81
Meloxicam 75
Gabapentin 72
Bexagliflozin 64
Ivermectin + Pyrantel As Pamoate Salt 62
Oclacitinib Maleate 50
Cefovecin 48
Milbemycin Oxime + Spinosad 48
Fluralaner Chew Tablets 45
Bedinvetmab 45
Famotidine 42
Desoxycorticosterone Pivalate 41
Buprenorphine 41
Maropitant 40
Moxidectin 40

Hypochloraemia Reaction Insights

1,640 reports name Hypochloraemia; 476 recorded a death outcome (29.0% of reported events, not a population-level mortality rate). VeDDRA code: 2578.

By species: Dog (1,212 reports), Cat (392 reports), Horse (33 reports). By breed: Domestic Shorthair (247), Retriever - Labrador (101), Crossbred Canine/dog (75).

Most co-reported drugs: Trilostane (418 reports), Maropitant Citrate (158 reports), Velagliflozin Proline Monohydrate (123 reports), Carprofen (118 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.