Reaction profile

The FDA adverse-event record for polyarthritis

75 FDA adverse-event reports reference polyarthritis (VeDDRA 574). See the species, breeds, and drugs most associated with it below.

75
reports citing this reaction
18.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
75
Total Reports
14
Deaths
18.7%
Death Rate

Species Most Affected

Dog 67
Cat 4
Cattle 3
Human 1

Breeds Most Affected

Retriever - Labrador 13
Boxer (German Boxer) 4
Retriever - Golden 4
Dog (unknown) 3
Collie - Border 3
Spaniel - Cocker American 3
Shepherd Dog - German 3
Crossbred Canine/dog 2
Domestic Mediumhair 2
Pointing Dog - Hungarian Short-haired (Vizsla) 2

Associated Drugs

Carprofen 13
Tramadol 10
Prednisone 10
Milbemycin Oxime + Spinosad 9
Maropitant Citrate 8
Doxycycline 8
Gabapentin 7
Oclacitinib Maleate 6
Afoxolaner 6
Bedinvetmab 6
Deracoxib 5
Polysulfated Glycosaminoglycan 5
Fluralaner Chew Tablets 5
Omeprazole 4
Antibiotic 4
Ivermectin + Pyrantel As Pamoate Salt 4
Meloxicam 4
Metronidazole 3
Grapiprant 3
Lotilaner 3

Polyarthritis Reaction Insights

75 reports name Polyarthritis; 14 recorded a death outcome (18.7% of reported events, not a population-level mortality rate). VeDDRA code: 574.

By species: Dog (67 reports), Cat (4 reports), Cattle (3 reports). By breed: Retriever - Labrador (13), Boxer (German Boxer) (4), Retriever - Golden (4).

Most co-reported drugs: Carprofen (13 reports), Tramadol (10 reports), Prednisone (10 reports), Milbemycin Oxime + Spinosad (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.