Flatulence

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VeDDRA Code: 269

1,205 adverse event reports referencing this reaction

1,205
Total Reports
65
Deaths
540.0%
Death Rate

Species Most Affected

Dog 1,123
Cat 55
Horse 13
Human 12
Unknown 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 134
Crossbred Canine/dog 110
Dog (unknown) 41
Retriever - Golden 40
Terrier - Yorkshire 36
Shepherd Dog - German 33
Chihuahua 32
Domestic Shorthair 31
Boxer (German Boxer) 29
Terrier - Boston 26

Associated Drugs

Fluralaner Chew Tablets 135
Milbemycin Oxime + Spinosad 125
Ivermectin + Pyrantel As Pamoate Salt 76
Afoxolaner 70
Carprofen 56
Milbemycin Oxime + Praziquantel 52
Maropitant Citrate 49
Grapiprant 49
Spinosad 40
Trilostane 40
Oclacitinib Maleate 40
Pyrantel Pamoate;Sarolaner 40
Fluralaner 13.64% 12-Week Chew 39
Gabapentin 30
Bedinvetmab 27
Moxidectin 26
Imidacloprid + Moxidectin 24
Cyclosporine A 24
Sarolaner 24
Metronidazole 21

Data Summary

Metric Value
Total reports referencing reaction 1,205
Reports with fatal outcome 65
Case-fatality rate (reported events) 540.0%
Species observed 6
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 269.

Flatulence Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 1,205 adverse event reports that reference Flatulence as a reaction term, including 65 reports with a death outcome — a 540.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 269, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Flatulence appears most frequently in reports for Dog (1,123 reports), Cat (55 reports), Horse (13 reports) — with Dog dominating at 1,123 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (134), Crossbred Canine/dog (110), Dog (unknown) (41). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Flatulence are Fluralaner Chew Tablets (135 reports), Milbemycin Oxime + Spinosad (125 reports), Ivermectin + Pyrantel As Pamoate Salt (76 reports), Afoxolaner (70 reports), with Fluralaner Chew Tablets appearing alongside this reaction in 135 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial