Reaction profile

The FDA adverse-event record for flatulence

1,205 FDA adverse-event reports reference flatulence (VeDDRA 269). See the species, breeds, and drugs most associated with it below.

1,205
reports citing this reaction
5.4%
death-coded share
Dog
most-affected species
Fluralaner Chew Tablets
most-associated drug
Verify with FDA CVM →
1,205
Total Reports
65
Deaths
5.4%
Death Rate

Species Most Affected

Dog 1,123
Cat 55
Horse 13
Human 12
Unknown 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 134
Crossbred Canine/dog 110
Dog (unknown) 41
Retriever - Golden 40
Terrier - Yorkshire 36
Shepherd Dog - German 33
Chihuahua 32
Domestic Shorthair 31
Boxer (German Boxer) 29
Terrier - Boston 26

Associated Drugs

Fluralaner Chew Tablets 135
Milbemycin Oxime + Spinosad 125
Ivermectin + Pyrantel As Pamoate Salt 76
Afoxolaner 70
Carprofen 56
Milbemycin Oxime + Praziquantel 52
Maropitant Citrate 49
Grapiprant 49
Spinosad 40
Trilostane 40
Oclacitinib Maleate 40
Pyrantel Pamoate;Sarolaner 40
Fluralaner 13.64% 12-Week Chew 39
Gabapentin 30
Bedinvetmab 27
Moxidectin 26
Imidacloprid + Moxidectin 24
Cyclosporine A 24
Sarolaner 24
Metronidazole 21

Flatulence Reaction Insights

1,205 reports name Flatulence; 65 recorded a death outcome (5.4% of reported events, not a population-level mortality rate). VeDDRA code: 269.

By species: Dog (1,123 reports), Cat (55 reports), Horse (13 reports). By breed: Retriever - Labrador (134), Crossbred Canine/dog (110), Dog (unknown) (41).

Most co-reported drugs: Fluralaner Chew Tablets (135 reports), Milbemycin Oxime + Spinosad (125 reports), Ivermectin + Pyrantel As Pamoate Salt (76 reports), Afoxolaner (70 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.