Reaction profile

The FDA adverse-event record for hypersensitivity to movement

74 FDA adverse-event reports reference hypersensitivity to movement (VeDDRA 707). See the species, breeds, and drugs most associated with it below.

74
reports citing this reaction
6.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
74
Total Reports
5
Deaths
6.8%
Death Rate

Species Most Affected

Dog 66
Cat 5
Horse 2
Pig 1

Breeds Most Affected

Retriever - Labrador 7
Boxer (German Boxer) 6
Terrier - Yorkshire 6
Shih Tzu 6
Domestic Shorthair 5
Crossbred Canine/dog 4
Chihuahua 4
Retriever - Golden 3
Terrier - Scottish 2
Horse (unknown) 2

Associated Drugs

Milbemycin Oxime + Spinosad 24
Sarolaner 12
Cephalexin 5
Afoxolaner 5
Buprenorphine 4
Ivermectin + Pyrantel As Pamoate Salt 4
Spinosad 3
Imidacloprid + Moxidectin 3
Enrofloxacin 3
Famotidine 3
Pyrantel Pamoate;Sarolaner 3
Ivermectin 2
Fish Oil 2
Cefovecin 2
Acepromazine 2
Atipamezole Hydrochloride 2
Ketamine 2
Maropitant Citrate 2
Gabapentin 2
Butorphanol 2

Hypersensitivity to movement Reaction Insights

74 reports name Hypersensitivity to movement; 5 recorded a death outcome (6.8% of reported events, not a population-level mortality rate). VeDDRA code: 707.

By species: Dog (66 reports), Cat (5 reports), Horse (2 reports). By breed: Retriever - Labrador (7), Boxer (German Boxer) (6), Terrier - Yorkshire (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (24 reports), Sarolaner (12 reports), Cephalexin (5 reports), Afoxolaner (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.