Warm feeling to the touch

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VeDDRA Code: 2742

646 adverse event reports referencing this reaction

646
Total Reports
44
Deaths
680.0%
Death Rate

Species Most Affected

Dog 467
Cat 155
Horse 11
Human 8
Cattle 3
Rabbit 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 94
Chihuahua 47
Retriever - Labrador 43
Crossbred Canine/dog 29
Terrier - Yorkshire 21
Retriever - Golden 21
Domestic Longhair 16
Shih Tzu 15
Shepherd Dog - German 15
Terrier (unspecified) 14

Associated Drugs

Afoxolaner 69
Nitenpyram 61
Pyrantel Pamoate;Sarolaner 39
Fluralaner 13.64% 12-Week Chew 36
Ivermectin + Pyrantel As Pamoate Salt 35
Milbemycin Oxime + Spinosad 27
Bedinvetmab 26
Gabapentin 25
Moxidectin 25
Lotilaner 25
Carprofen 24
Prednisone 21
Diphenhydramine 20
Buprenorphine 19
Selamectin;Sarolaner 16
Maropitant Citrate 15
Fluralaner Spot-On Solution 14
Butorphanol 14
Tigilanol Tiglate 14
Praziquantel + Pyrantel Pamoate 13

Data Summary

Metric Value
Total reports referencing reaction 646
Reports with fatal outcome 44
Case-fatality rate (reported events) 680.0%
Species observed 7
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2742.

Warm feeling to the touch Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 646 adverse event reports that reference Warm feeling to the touch as a reaction term, including 44 reports with a death outcome — a 680.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2742, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Warm feeling to the touch appears most frequently in reports for Dog (467 reports), Cat (155 reports), Horse (11 reports) — with Dog dominating at 467 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (94), Chihuahua (47), Retriever - Labrador (43). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Warm feeling to the touch are Afoxolaner (69 reports), Nitenpyram (61 reports), Pyrantel Pamoate;Sarolaner (39 reports), Fluralaner 13.64% 12-Week Chew (36 reports), with Afoxolaner appearing alongside this reaction in 69 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial