Reaction profile

The FDA adverse-event record for warm feeling to the touch

646 FDA adverse-event reports reference warm feeling to the touch (VeDDRA 2742). See the species, breeds, and drugs most associated with it below.

646
reports citing this reaction
6.8%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
646
Total Reports
44
Deaths
6.8%
Death Rate

Species Most Affected

Dog 467
Cat 155
Horse 11
Human 8
Cattle 3
Rabbit 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 94
Chihuahua 47
Retriever - Labrador 43
Crossbred Canine/dog 29
Terrier - Yorkshire 21
Retriever - Golden 21
Domestic Longhair 16
Shih Tzu 15
Shepherd Dog - German 15
Terrier (unspecified) 14

Associated Drugs

Afoxolaner 69
Nitenpyram 61
Pyrantel Pamoate;Sarolaner 39
Fluralaner 13.64% 12-Week Chew 36
Ivermectin + Pyrantel As Pamoate Salt 35
Milbemycin Oxime + Spinosad 27
Bedinvetmab 26
Gabapentin 25
Moxidectin 25
Lotilaner 25
Carprofen 24
Prednisone 21
Diphenhydramine 20
Buprenorphine 19
Selamectin;Sarolaner 16
Maropitant Citrate 15
Fluralaner Spot-On Solution 14
Butorphanol 14
Tigilanol Tiglate 14
Praziquantel + Pyrantel Pamoate 13

Warm feeling to the touch Reaction Insights

646 reports name Warm feeling to the touch; 44 recorded a death outcome (6.8% of reported events, not a population-level mortality rate). VeDDRA code: 2742.

By species: Dog (467 reports), Cat (155 reports), Horse (11 reports). By breed: Domestic Shorthair (94), Chihuahua (47), Retriever - Labrador (43).

Most co-reported drugs: Afoxolaner (69 reports), Nitenpyram (61 reports), Pyrantel Pamoate;Sarolaner (39 reports), Fluralaner 13.64% 12-Week Chew (36 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.