Reaction profile

The FDA adverse-event record for ineffective, cushings

1,037 FDA adverse-event reports reference ineffective, cushings (VeDDRA 99095). See the species, breeds, and drugs most associated with it below.

1,037
reports citing this reaction
6.7%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,037
Total Reports
69
Deaths
6.7%
Death Rate

Species Most Affected

Dog 988
Horse 48
Other 1

Breeds Most Affected

Beagle 66
Retriever - Labrador 64
Shih Tzu 58
Chihuahua 51
Terrier - Boston 47
Maltese 47
Crossbred Canine/dog 42
Boxer (German Boxer) 38
Terrier - Yorkshire 34
Dachshund - Miniature 32

Associated Drugs

Trilostane 1,584
Pergolide Mesylate 48
Levothyroxine 28
Gabapentin 23
Insulin 16
Carprofen 15
Enalapril 12
Tramadol 10
Ursodiol 10
Selegiline Hcl 9
Compounded Trilostane 9
Oclacitinib 8
Fluoxetine 7
Same And Silybin 7
Oclacitinib Maleate 7
Levothyroxine Sodium 6
Benazepril 6
Phenobarbital 6
Trazodone 6
Prescription Diet 6

INEFFECTIVE, CUSHINGS Reaction Insights

1,037 reports name INEFFECTIVE, CUSHINGS; 69 recorded a death outcome (6.7% of reported events, not a population-level mortality rate). VeDDRA code: 99095.

By species: Dog (988 reports), Horse (48 reports), Other (1 reports). By breed: Beagle (66), Retriever - Labrador (64), Shih Tzu (58).

Most co-reported drugs: Trilostane (1,584 reports), Pergolide Mesylate (48 reports), Levothyroxine (28 reports), Gabapentin (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.