Reaction profile

The FDA adverse-event record for contamination nos

491 FDA adverse-event reports reference contamination nos (VeDDRA 99008). See the species, breeds, and drugs most associated with it below.

491
reports citing this reaction
1.4%
death-coded share
Unknown
most-affected species
Ivermectin, Pyrantel
most-associated drug
Verify with FDA CVM →
491
Total Reports
7
Deaths
1.4%
Death Rate

Species Most Affected

Unknown 461
Dog 18
Cattle 4
Cat 4
Horse 2
Human 1
Rat 1

Breeds Most Affected

Unknown 463
Dog (unknown) 5
Retriever - Labrador 4
Holstein-Friesian also known as Holstein 2
Cat (unknown) 2
Crossbred Canine/dog 2
Domestic Shorthair 2
Mixed (Horse) 1
Shih Tzu 1
Cattle (other) 1

Associated Drugs

Ivermectin, Pyrantel 79
Enrofloxacin 43
Oxytetracycline Dihydrate 34
Moxidectin 22
Flunixin Meglumine 17
Ivermectin + Pyrantel As Pamoate Salt 16
Carprofen 13
Clorsulon + Ivermectin 13
Ivermectin 12
Flunixin Meglumine Injectable 12
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 11
Furosemide 10
Ceftiofur Sodium 9
Milbemycin 9
Insulin Injectable Vial 9
Cefovecin 9
Ivermectin + Pyrantel 8
Fluralaner 13.64% 12-Week Chew 7
Butorphanol Tartrate 6
Melarsomine 6

Contamination NOS Reaction Insights

491 reports name Contamination NOS; 7 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). VeDDRA code: 99008.

By species: Unknown (461 reports), Dog (18 reports), Cattle (4 reports). By breed: Unknown (463), Dog (unknown) (5), Retriever - Labrador (4).

Most co-reported drugs: Ivermectin, Pyrantel (79 reports), Enrofloxacin (43 reports), Oxytetracycline Dihydrate (34 reports), Moxidectin (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.