Reaction profile

The FDA adverse-event record for muscle atrophy (see also muscle wasting)

255 FDA adverse-event reports reference muscle atrophy (see also muscle wasting) (VeDDRA 2470). See the species, breeds, and drugs most associated with it below.

255
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
255
Total Reports
61
Deaths
23.9%
Death Rate

Species Most Affected

Dog 203
Cat 38
Horse 12
Cougar 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 45
Domestic Shorthair 25
Shepherd Dog - German 20
Crossbred Canine/dog 14
Retriever - Golden 11
Terrier - Bull - American Pit 10
Rottweiler 6
Boxer (German Boxer) 6
Terrier (unspecified) 6
Domestic Longhair 5

Associated Drugs

Bedinvetmab 144
Gabapentin 54
Carprofen 45
Frunevetmab 18
Prednisone 16
Trilostane 16
Maropitant Citrate 15
Oclacitinib Maleate 13
Polysulfated Glycosaminoglycan 11
Meloxicam 11
Galliprant 11
Grapiprant 11
Afoxolaner 7
Anti-Il31 Mab Mcs Lot #1283563 7
Cyclosporine 7
Milbemycin Oxime + Praziquantel 7
Amoxicillin 7
Fish Oil 6
Fluid Therapy 6
Doxycycline 6

Muscle atrophy (see also Muscle wasting) Reaction Insights

255 reports name Muscle atrophy (see also Muscle wasting); 61 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 2470.

By species: Dog (203 reports), Cat (38 reports), Horse (12 reports). By breed: Retriever - Labrador (45), Domestic Shorthair (25), Shepherd Dog - German (20).

Most co-reported drugs: Bedinvetmab (144 reports), Gabapentin (54 reports), Carprofen (45 reports), Frunevetmab (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.