Reaction profile

The FDA adverse-event record for lip erythema

75 FDA adverse-event reports reference lip erythema (VeDDRA 2447). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1538 of 2,481
by report volume (all reactions)
75
reports citing this reaction
1.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lip erythema has 75 reports now versus 73 in that prior snapshot: 2 more (2.7%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lip erythema changes

FDA AER · VeDDRA plate

Code 2447 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 75 reports
  • DEATH-LOW 1.3%
  • MID-PACK #1538/2481
  • PHOTO-FINISH Gall bladder mucocele
  • SPECIES-DOG Dog · 50
  • DRUG-LEAD Ivermectin(1.55%)… · 13
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gall bladder mucocele (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Lip erythema

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Gall bladder mucocele · near75Hypersensitivity to l… · near75Hypersensitivity to m… · near75Lip erythema · this reaction75Tooth loss · near75Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lip erythema

Lip erythema: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for Lip erythema in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 1 of 75 reports (1.3% of named reports). Nearest volume peer: Gall bladder mucocele (±0 reports). Lead species Dog (50). Lead co-reported drug Ivermectin(1.55%)/Praziquantel(7.75%) Paste (13).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin(1.55%)/Praziquantel(7.75%) Paste appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 50
Horse 16
Cat 5
Human 4

Breeds Most Affected

Crossbred Canine/dog 7
Retriever - Labrador 6
Thoroughbred 5
Horse (unknown) 4
Unknown 4
Shepherd Dog - Australian 4
Shih Tzu 3
Retriever - Golden 3
Chihuahua 3
Hanovarian 2

Associated Drugs

Ivermectin(1.55%)/Praziquantel(7.75%) Paste 13
Moxidectin 9
Afoxolaner 6
Fluralaner Chew Tablets 5
Ivermectin + Pyrantel As Pamoate Salt 4
Melarsomine Dihydrochloride 4
Cefovecin 3
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 3
Imidacloprid + Moxidectin 3
Ivermectin + Praziquantel 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Maropitant Citrate 2
Carprofen 2
Selamectin;Sarolaner 2
Fluralaner 13.64% 12-Week Chew 2
Trilostane 2
Milbemycin Oxime 2
Imidacloprid, Flumethrin 2
Firocoxib 57 Mg Chewable 1
Omega 3 Fatty Acid 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lip erythema, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (75 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lip erythema (#1538 of 2,481 by report volume); death-coded 1.3%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →