Reaction profile

The FDA adverse-event record for confusion

2,259 FDA reports name confusion, a high-volume reaction in the CVM extract (VeDDRA 659). Plate stamps and neighbourhood peers follow.

#205 of 2,481
by report volume (all reactions)
2,259
reports citing this reaction
14.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Confusion has 2,259 reports now versus 2,213 in that prior snapshot: 46 more (2.1%).

Report change
+46
Death-coded reports
+6
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Confusion changes

FDA AER · VeDDRA plate

Code 659 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,259 reports
  • DEATH-ELEV 14.8%
  • TOP-DECILE #205/2481
  • PHOTO-FINISH Stumbling gait
  • SPECIES-DOG Dog · 1,948
  • DRUG-LEAD Bedinvetmab · 271
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Stumbling gait (±7 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Confusion

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Anaphylactoid reaction · near2272Confusion · this reaction2259Stumbling gait · near2252Low platelet count · near2247Caps, Abnormal · near2242Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Confusion

What the FDA AER plate says about Confusion

Signature read: 334 death-coded reports is a heavy tail count for Confusion in the CVM extract. Report volume is upper-third scale: 2,259 named reports in the openFDA extract. 334 of 2,259 reports were death-coded (14.8% of named reports, not a population mortality rate). Nearest volume peer: Stumbling gait (±7 reports). Lead species Dog (1,948). Lead co-reported drug Bedinvetmab (271).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,948
Cat 293
Horse 13
Cattle 4
Unknown 1

Breeds Most Affected

Crossbred Canine/dog 234
Retriever - Labrador 195
Domestic Shorthair 121
Chihuahua 86
Domestic (unspecified) 85
Retriever - Golden 74
Terrier - Yorkshire 68
Dog (unknown) 67
Shepherd Dog - German 59
Boxer (German Boxer) 49

Associated Drugs

Bedinvetmab 271
Milbemycin Oxime + Spinosad 215
Spinosad 162
Carprofen 149
Afoxolaner 130
Pyrantel Pamoate;Sarolaner 104
Gabapentin 82
Maropitant Citrate 79
Fluralaner 13.64% 12-Week Chew 73
Oclacitinib Maleate 64
Ivermectin + Pyrantel As Pamoate Salt 60
Trilostane 58
Sarolaner 56
Ivermectin 50
Meloxicam 50
Buprenorphine 46
Selamectin 44
Fluralaner Chew Tablets 39
Grapiprant 36
Prednisone 33

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Confusion, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,259 here).

Similar death-coded share

Nearest other reactions by death-coded share (14.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Confusion (#205 of 2,481 by report volume); death-coded 14.8%. PlainBreed reaction plate · death-coded report count stamp 334 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →