Reaction profile

The FDA adverse-event record for injection site reddening

315 FDA adverse-event reports reference injection site reddening (VeDDRA 1552). See the species, breeds, and drugs most associated with it below.

315
reports citing this reaction
2.5%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
315
Total Reports
8
Deaths
2.5%
Death Rate

Species Most Affected

Dog 190
Human 78
Cat 43
Horse 2
Unknown 1
Cattle 1

Breeds Most Affected

Unknown 81
Domestic Shorthair 28
Retriever - Labrador 23
Terrier - Yorkshire 11
Retriever - Golden 9
Pit Bull 8
Maltese 7
Terrier - Bull - American Pit 7
Dog (unknown) 7
Boxer (German Boxer) 6

Associated Drugs

Tigilanol Tiglate 82
Diphenhydramine 45
Prednisone 38
Famotidine 36
Carprofen 32
Gabapentin 31
Maropitant Citrate 28
Butorphanol 26
Moxidectin 24
Dexmedetomidine 21
Cefovecin 19
Butorphanol Tartrate 19
Buprenorphine 15
Atipamezole 15
Atipamezole Hydrochloride 15
Bedinvetmab 14
Propofol 12
Frunevetmab 12
Dexmedetomidine Hydrochloride 12
Ketamine 10

Injection site reddening Reaction Insights

315 reports name Injection site reddening; 8 recorded a death outcome (2.5% of reported events, not a population-level mortality rate). VeDDRA code: 1552.

By species: Dog (190 reports), Human (78 reports), Cat (43 reports). By breed: Unknown (81), Domestic Shorthair (28), Retriever - Labrador (23).

Most co-reported drugs: Tigilanol Tiglate (82 reports), Diphenhydramine (45 reports), Prednisone (38 reports), Famotidine (36 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.