Reaction profile

The FDA adverse-event record for tongue protrusion

Name: Tongue protrusion - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

434 FDA reports name tongue protrusion, a high-volume reaction in the CVM extract (VeDDRA 1078). Plate stamps and neighbourhood peers follow.

#692 of 2,481
by report volume (all reactions): 434
reports citing this reaction: 20.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tongue protrusion has 434 reports now versus 427 in that prior snapshot: 7 more (1.6%).

Report change: +7
Death-coded reports: +0
Death-coded share: −0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tongue protrusion changes

FDA AER · VeDDRA plate

Code 1078 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 434 reports
DEATH-HOT 20.3%
MID-PACK #692/2481
PHOTO-FINISH Congestive heart fail…
SPECIES-DOG Dog · 239
DRUG-LEAD Afoxolaner · 43
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Congestive heart failure (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Tongue protrusion

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Tongue protrusion

What the FDA AER plate says about Tongue protrusion

Signature read: 88 death-coded reports is a heavy tail count for Tongue protrusion in the CVM extract. Report volume is upper-third scale: 434 named reports in the openFDA extract. 88 of 434 reports were death-coded (20.3% of named reports, not a population mortality rate). Nearest volume peer: Congestive heart failure (±1 reports). Lead species Dog (239). Lead co-reported drug Afoxolaner (43).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 239

Cat 150

Horse 37

Cattle 3

Donkey 2

Goat 1

Human 1

Unknown 1

Breeds Most Affected

Domestic Shorthair 86

Chihuahua 16

Domestic Mediumhair 16

Crossbred Canine/dog 16

Retriever - Labrador 14

Terrier - Yorkshire 14

Shepherd Dog - German 13

Cat (unknown) 13

Retriever - Golden 11

Domestic Longhair 10

Associated Drugs

Afoxolaner 43

Nitenpyram 34

Eprinomectin + Esafoxolaner + Praziquantel 34

Ivermectin + Pyrantel As Pamoate Salt 25

Spinosad 24

Ivermectin + Praziquantel 22

Milbemycin Oxime + Spinosad 19

Fluralaner 13.64% 12-Week Chew 15

Carprofen 14

Pyrantel Pamoate;Sarolaner 14

Cefovecin 12

Maropitant Citrate 12

Milbemycin Oxime + Praziquantel 12

Fluralaner Chew Tablets 11

Buprenorphine 11

Gabapentin 10

Ivermectin 8

Ivermectin(1.55%)/Praziquantel(7.75%) Paste 8

Oclacitinib Maleate 8

Fluralaner Spot-On Solution 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Tongue protrusion, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (434 here).

Congestive heart failure 435 Dermal cyst(s) 433 Erythematous rash 432 Food refusal 431

Similar death-coded share

Nearest other reactions by death-coded share (20.3% here), distinct from the volume row.

Bronchopulmonary inflammation 20.3% Central vestibular disorder 20.3% Retinal detachment 20.2% Collapse of leg 20.2%

What to do with this reaction

Compare Tongue protrusion's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tongue protrusion (#692 of 2,481 by report volume); death-coded 20.3%. PlainBreed reaction plate · death-coded report count stamp 88 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →