Reaction profile

The FDA adverse-event record for tongue protrusion

417 FDA adverse-event reports reference tongue protrusion (VeDDRA 1078). See the species, breeds, and drugs most associated with it below.

417
reports citing this reaction
20.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
417
Total Reports
87
Deaths
20.9%
Death Rate

Species Most Affected

Dog 232
Cat 140
Horse 37
Cattle 3
Donkey 2
Goat 1
Human 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 82
Chihuahua 15
Crossbred Canine/dog 15
Terrier - Yorkshire 14
Shepherd Dog - German 13
Domestic Mediumhair 13
Cat (unknown) 13
Retriever - Labrador 12
Retriever - Golden 10
Shih Tzu 9

Associated Drugs

Afoxolaner 42
Nitenpyram 32
Eprinomectin + Esafoxolaner + Praziquantel 28
Ivermectin + Pyrantel As Pamoate Salt 25
Spinosad 24
Ivermectin + Praziquantel 22
Milbemycin Oxime + Spinosad 19
Fluralaner 13.64% 12-Week Chew 15
Carprofen 14
Cefovecin 12
Milbemycin Oxime + Praziquantel 12
Pyrantel Pamoate;Sarolaner 12
Maropitant Citrate 11
Fluralaner Chew Tablets 11
Buprenorphine 11
Gabapentin 9
Ivermectin 8
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 8
Fluralaner Spot-On Solution 8
Sarolaner 8

Tongue protrusion Reaction Insights

417 reports name Tongue protrusion; 87 recorded a death outcome (20.9% of reported events, not a population-level mortality rate). VeDDRA code: 1078.

By species: Dog (232 reports), Cat (140 reports), Horse (37 reports). By breed: Domestic Shorthair (82), Chihuahua (15), Crossbred Canine/dog (15).

Most co-reported drugs: Afoxolaner (42 reports), Nitenpyram (32 reports), Eprinomectin + Esafoxolaner + Praziquantel (28 reports), Ivermectin + Pyrantel As Pamoate Salt (25 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.