Reaction profile

The FDA adverse-event record for diabetes

741 FDA adverse-event reports reference diabetes (VeDDRA 387). See the species, breeds, and drugs most associated with it below.

741
reports citing this reaction
19.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
741
Total Reports
147
Deaths
19.8%
Death Rate

Species Most Affected

Dog 591
Cat 149
Horse 1

Breeds Most Affected

Domestic Shorthair 86
Dog (unknown) 54
Retriever - Labrador 53
Chihuahua 33
Schnauzer - Miniature 30
Crossbred Canine/dog 23
Pinscher - Miniature 23
Shih Tzu 22
Schnauzer (unspecified) 22
Terrier - Yorkshire 21

Associated Drugs

Trilostane 164
Milbemycin Oxime + Spinosad 110
Oclacitinib Maleate 66
Bedinvetmab 63
Cyclosporine 46
Spinosad 43
Insulin 39
Carprofen 31
Frunevetmab 27
Imidacloprid + Moxidectin 25
Prednisone 22
Gabapentin 21
Methylprednisolone Acetate 19
Milbemycin Oxime + Praziquantel 19
Maropitant Citrate 18
Prednisolone 17
Cefovecin 17
Moxidectin 15
Fluralaner Chew Tablets 15
Ivermectin + Pyrantel As Pamoate Salt 15

Diabetes Reaction Insights

741 reports name Diabetes; 147 recorded a death outcome (19.8% of reported events, not a population-level mortality rate). VeDDRA code: 387.

By species: Dog (591 reports), Cat (149 reports), Horse (1 reports). By breed: Domestic Shorthair (86), Dog (unknown) (54), Retriever - Labrador (53).

Most co-reported drugs: Trilostane (164 reports), Milbemycin Oxime + Spinosad (110 reports), Oclacitinib Maleate (66 reports), Bedinvetmab (63 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.