Reaction profile
The FDA adverse-event record for joint stiffness
151 FDA adverse-event reports reference joint stiffness (VeDDRA 573). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.
- #1181 of 2,481
- by report volume (all reactions)
- 151
- reports citing this reaction
- 13.2%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Joint stiffness has 151 reports now versus 145 in that prior snapshot: 6 more (4.1%).
- Report change
- +6
- Death-coded reports
- +0
- Death-coded share
- −0.5 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Joint stiffness changesFDA AER · VeDDRA plate
Code 573 VOL-LOW
VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-LOW 151 reports
- DEATH-ELEV 13.2%
- MID-PACK #1181/2481
- PHOTO-FINISH Bulging eye
- SPECIES-DOG Dog · 118
- DRUG-LEAD Trilostane · 24
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Bulging eye (±0 reports)
Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.
Report-volume neighbourhood around Joint stiffness
Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.
What the FDA AER plate says about Joint stiffness
Signature read: death-coded share at 13.2% is the most distinctive outcome stamp on Joint stiffness. Report volume sits in the middle third of the reaction corpus. 20 of 151 reports were death-coded (13.2% of named reports, not a population mortality rate). Nearest volume peer: Bulging eye (±0 reports). Lead species Dog (118). Lead co-reported drug Trilostane (24).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Joint stiffness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (151 here).
Similar death-coded share
Nearest other reactions by death-coded share (13.2% here), distinct from the volume row.
What to do with this reaction
- Compare Joint stiffness's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →