Reaction profile

The FDA adverse-event record for milk production decrease

333 FDA adverse-event reports reference milk production decrease (VeDDRA 535). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#833 of 2,481
by report volume (all reactions)
333
reports citing this reaction
17.4%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Milk production decrease has 333 reports now versus 325 in that prior snapshot: 8 more (2.5%).

Report change
+8
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Milk production decrease changes

FDA AER · VeDDRA plate

Code 535 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 333 reports
  • DEATH-ELEV 17.4%
  • MID-PACK #833/2481
  • PHOTO-FINISH Circling - behavioura…
  • SPECIES-CATTLE Cattle · 310
  • DRUG-LEAD Monensin Sodium · 207
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Circling - behavioural disorder (see also Neurological disorders) (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Milk production decrease

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Crackles on auscultat… · near335Abnormal red blood ce… · near334Surgical site disorder · near334Circling - behavioura… · near333Milk production decre… · thi…333Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Milk production decrease

What the FDA AER plate says about Milk production decrease

Signature read: 58 death-coded reports is a heavy tail count for Milk production decrease in the CVM extract. Report volume sits in the middle third of the reaction corpus. 58 of 333 reports were death-coded (17.4% of named reports, not a population mortality rate). Nearest volume peer: Circling - behavioural disorder (see also Neurological disorders) (±0 reports). Lead species Cattle (310). Lead co-reported drug Monensin Sodium (207).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Monensin Sodium appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 310
Dog 13
Cat 4
Goat 2
Sheep 2
Horse 1
Pig 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 211
Cattle (unknown) 34
Jersey 18
Crossbred Bovine/Cattle 15
Mixed (Cattle) 14
Cattle (other) 12
Bulldog - French 3
Bulldog 2
Domestic Shorthair 2
Siberian Husky 2

Associated Drugs

Monensin Sodium 207
Sometribove 76
Monensin 18
Ceftiofur 6
Sometribove Zinc Suspension 6
Eprinomectin 6
Moxidectin 5
3-Nitrooxypropanol 5
Ampicillin Trihydrate 3
Fenbendazol Pellets 3
Fenbendazole 2
Dinoprost Tromethamine 2
Nitenpyram 2
Flunixin Meglumine 2
Oxytocin 2
Ceftiofur Crystalline Free Acid 2
Meloxicam 2
Cefovecin 2
Eprinomectin 5 Mg/Ml Pour-On Solution 2
Cephapirin Sodium 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Milk production decrease, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Milk production decrease (#833 of 2,481 by report volume); death-coded 17.4%. PlainBreed reaction plate · death-coded report count stamp 58 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →