Reaction profile

The FDA adverse-event record for muscle tremor

2,237 FDA adverse-event reports reference muscle tremor (VeDDRA 684). See the species, breeds, and drugs most associated with it below.

2,237
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
2,237
Total Reports
222
Deaths
9.9%
Death Rate

Species Most Affected

Dog 1,665
Cat 499
Horse 46
Cattle 9
Pig 7
Other Birds 2
Donkey 2
Mouse 1
Human 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 352
Retriever - Labrador 155
Chihuahua 101
Crossbred Canine/dog 98
Terrier - Yorkshire 97
Shih Tzu 59
Maltese 57
Retriever - Golden 52
Boxer (German Boxer) 52
Dachshund (unspecified) 47

Associated Drugs

Imidacloprid + Moxidectin 338
Milbemycin Oxime + Spinosad 271
Sarolaner 194
Selamectin 135
Emodepside + Praziquantel 121
Pyrantel Pamoate;Sarolaner 115
Afoxolaner 97
Spinosad 85
Maropitant Citrate 68
Trilostane 59
Ivermectin 58
Fluralaner 13.64% 12-Week Chew 54
Fluralaner Chew Tablets 52
Moxidectin 51
Carprofen 51
Cefovecin 39
Ivermectin + Pyrantel As Pamoate Salt 38
Lotilaner 37
Enrofloxacin 35
Methocarbamol 34

Muscle tremor Reaction Insights

2,237 reports name Muscle tremor; 222 recorded a death outcome (9.9% of reported events, not a population-level mortality rate). VeDDRA code: 684.

By species: Dog (1,665 reports), Cat (499 reports), Horse (46 reports). By breed: Domestic Shorthair (352), Retriever - Labrador (155), Chihuahua (101).

Most co-reported drugs: Imidacloprid + Moxidectin (338 reports), Milbemycin Oxime + Spinosad (271 reports), Sarolaner (194 reports), Selamectin (135 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.