Reaction profile

The FDA adverse-event record for containers, abnormal

2,232 FDA adverse-event reports reference containers, abnormal (VeDDRA 99004). See the species, breeds, and drugs most associated with it below.

2,232
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
2,232
Total Reports
1
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 2,203
Dog 18
Human 7
Cat 3
Cattle 1

Breeds Most Affected

Unknown 2,210
Dog (unknown) 2
Terrier - Yorkshire 1
Collie - Border 1
Maltese 1
Retriever - Golden 1
Dachshund (unspecified) 1
Domestic Longhair 1
Cattle (other) 1
Corgi - Welsh Pembroke 1

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 180
Meloxicam 163
Afoxolaner 152
Ivermectin, Pyrantel 142
Pyrantel Pamoate;Sarolaner 83
Mirtazapine 78
Tulathromycin 57
Moxidectin 51
Sarolaner 47
Trilostane 42
Afoxolaner 28.3 Mg Chewable Tablets 37
Ivermectin 32
Zeranol 32
Selamectin 29
Dexamethasone + Neomycin Sulfate + Thiabendazole 24
Firocoxib 22
Cyclosporine 22
Insulin Injectable Vial 22
Carprofen 21
Maropitant Citrate 21

Containers, Abnormal Reaction Insights

2,232 reports name Containers, Abnormal; 1 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99004.

By species: Unknown (2,203 reports), Dog (18 reports), Human (7 reports). By breed: Unknown (2,210), Dog (unknown) (2), Terrier - Yorkshire (1).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (180 reports), Meloxicam (163 reports), Afoxolaner (152 reports), Ivermectin, Pyrantel (142 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.