Reaction profile

The FDA adverse-event record for balance impaired

675 FDA adverse-event reports reference balance impaired (VeDDRA 1341). See the species, breeds, and drugs most associated with it below.

675
reports citing this reaction
11.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
675
Total Reports
76
Deaths
11.3%
Death Rate

Species Most Affected

Dog 532
Cat 130
Horse 7
Cattle 2
Sheep 1
Rat 1
Other Equids 1
Human 1

Breeds Most Affected

Domestic Shorthair 85
Retriever - Labrador 70
Crossbred Canine/dog 48
Terrier - Yorkshire 27
Chihuahua 21
Retriever - Golden 19
Boxer (German Boxer) 15
Shepherd Dog - German 15
Pit Bull 15
Shepherd Dog - Australian 14

Associated Drugs

Milbemycin Oxime + Spinosad 71
Afoxolaner 67
Fluralaner 13.64% 12-Week Chew 46
Pyrantel Pamoate;Sarolaner 42
Bedinvetmab 41
Sarolaner 37
Fluralaner Chew Tablets 33
Ivermectin + Pyrantel As Pamoate Salt 30
Gabapentin 29
Carprofen 28
Maropitant Citrate 26
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 19
Cefovecin 18
Fluralaner Spot-On Solution 17
Frunevetmab 15
Nitenpyram 14
Spinosad 13
Genta/Momet/Clotrim Ear Oint 13
Grapiprant 13
Polysulfated Glycosaminoglycan 13

Balance impaired Reaction Insights

675 reports name Balance impaired; 76 recorded a death outcome (11.3% of reported events, not a population-level mortality rate). VeDDRA code: 1341.

By species: Dog (532 reports), Cat (130 reports), Horse (7 reports). By breed: Domestic Shorthair (85), Retriever - Labrador (70), Crossbred Canine/dog (48).

Most co-reported drugs: Milbemycin Oxime + Spinosad (71 reports), Afoxolaner (67 reports), Fluralaner 13.64% 12-Week Chew (46 reports), Pyrantel Pamoate;Sarolaner (42 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.