Reaction profile

The FDA adverse-event record for trauma nos

712 FDA adverse-event reports reference trauma nos (VeDDRA 1932). See the species, breeds, and drugs most associated with it below.

712
reports citing this reaction
23.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
712
Total Reports
164
Deaths
23.0%
Death Rate

Species Most Affected

Dog 569
Cat 64
Cattle 35
Human 20
Horse 12
Pig 8
Turkey 2
Other 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 71
Crossbred Canine/dog 44
Dog (unknown) 38
Domestic Shorthair 36
Shepherd Dog - German 29
Chihuahua 27
Unknown 22
Pit Bull 18
Shih Tzu 17
Boxer (German Boxer) 17

Associated Drugs

Milbemycin Oxime + Spinosad 347
Spinosad 70
Milbemycin Oxime + Praziquantel 66
Deracoxib 26
Grapiprant 22
Carprofen 20
Ivermectin 20
Milbemycin Oxime 19
Fluralaner Chew Tablets 17
Imidacloprid + Moxidectin 16
Trilostane 16
Ivermectin + Pyrantel As Pamoate Salt 16
Ractopamine Hydrochloride 15
Rabies Vaccine 15
Lotilaner 15
Gabapentin 14
Monensin Sodium 13
Diphenhydramine 11
Buprenorphine 11
Robenacoxib 11

Trauma NOS Reaction Insights

712 reports name Trauma NOS; 164 recorded a death outcome (23.0% of reported events, not a population-level mortality rate). VeDDRA code: 1932.

By species: Dog (569 reports), Cat (64 reports), Cattle (35 reports). By breed: Retriever - Labrador (71), Crossbred Canine/dog (44), Dog (unknown) (38).

Most co-reported drugs: Milbemycin Oxime + Spinosad (347 reports), Spinosad (70 reports), Milbemycin Oxime + Praziquantel (66 reports), Deracoxib (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.