Reaction profile

The FDA adverse-event record for eyes rolling back

785 FDA reports name eyes rolling back, a high-volume reaction in the CVM extract (VeDDRA 2084). Plate stamps and neighbourhood peers follow.

#463 of 2,481
by report volume (all reactions)
785
reports citing this reaction
6.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eyes rolling back has 785 reports now versus 776 in that prior snapshot: 9 more (1.2%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eyes rolling back changes

FDA AER · VeDDRA plate

Code 2084 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 785 reports
  • DEATH-PAR 6.2%
  • UPPER-Q #463/2481
  • PHOTO-FINISH Haematemesis
  • SPECIES-DOG Dog · 720
  • DRUG-LEAD Milbemycin Oxime… · 375
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Haematemesis (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Eyes rolling back

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Eyes rolling back · this rea…785Haematemesis · near785Stiffness limb · near782Injection site bleedi… · near780Diabetes · near777Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Eyes rolling back

Eyes rolling back: low death-coded share in the FDA AER plate

Signature read: 785 reports place Eyes rolling back in the upper third of FDA AER volume (#463 of 2,481). Report volume is upper-third scale: 785 named reports in the openFDA extract. Death-coded share is lower-third: 49 of 785 reports (6.2% of named reports). Nearest volume peer: Haematemesis (±0 reports). Lead species Dog (720). Lead co-reported drug Milbemycin Oxime + Spinosad (375).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 720
Cat 45
Horse 13
Cattle 5
Other 1
Pig 1

Breeds Most Affected

Retriever - Labrador 68
Retriever - Golden 65
Boxer (German Boxer) 61
Crossbred Canine/dog 51
Chihuahua 28
Terrier - Yorkshire 26
Shepherd Dog - German 22
Pit Bull 22
Domestic Shorthair 22
Maltese 16

Associated Drugs

Milbemycin Oxime + Spinosad 375
Afoxolaner 96
Spinosad 64
Ivermectin + Pyrantel As Pamoate Salt 31
Maropitant Citrate 28
Pyrantel Pamoate;Sarolaner 27
Fluralaner Chew Tablets 21
Fluralaner 13.64% 12-Week Chew 21
Sarolaner 17
Ivermectin 16
Carprofen 16
Bedinvetmab 16
Milbemycin Oxime + Praziquantel 15
Diphenhydramine 10
Moxidectin 10
Prednisone 9
Lotilaner 9
Gabapentin 9
Buprenorphine 9
Cefovecin 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Eyes rolling back, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (785 here).

Similar death-coded share

Nearest other reactions by death-coded share (6.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eyes rolling back (#463 of 2,481 by report volume); death-coded 6.2%. PlainBreed reaction plate · report volume stamp 785 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →