Reaction profile

The FDA adverse-event record for nephropathy

143 FDA adverse-event reports reference nephropathy (VeDDRA 717). See the species, breeds, and drugs most associated with it below.

143
reports citing this reaction
32.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
143
Total Reports
47
Deaths
32.9%
Death Rate

Species Most Affected

Dog 123
Cat 18
Mule 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 15
Domestic Shorthair 12
Retriever - Golden 12
Crossbred Canine/dog 9
Beagle 6
Dog (unknown) 6
Shepherd Dog - Australian 5
Terrier - Yorkshire 4
Maltese 4
Terrier - Boston 4

Associated Drugs

Carprofen 25
Maropitant Citrate 21
Trilostane 19
Oclacitinib Maleate 17
Bedinvetmab 14
Gabapentin 13
Doxycycline 9
Grapiprant 9
Enrofloxacin 8
Prednisone 8
Fluralaner Chew Tablets 8
Milbemycin Oxime + Spinosad 7
Buprenorphine 7
Famotidine 6
Afoxolaner 6
Metronidazole 5
Polysulfated Glycosaminoglycan 5
Milbemycin Oxime + Praziquantel 5
Deracoxib 4
Anesthetic 4

Nephropathy Reaction Insights

143 reports name Nephropathy; 47 recorded a death outcome (32.9% of reported events, not a population-level mortality rate). VeDDRA code: 717.

By species: Dog (123 reports), Cat (18 reports), Mule (1 reports). By breed: Retriever - Labrador (15), Domestic Shorthair (12), Retriever - Golden (12).

Most co-reported drugs: Carprofen (25 reports), Maropitant Citrate (21 reports), Trilostane (19 reports), Oclacitinib Maleate (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.