Fipronil
1,753 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,753
Total Reports
71
Deaths Reported
410.0%
Death Rate
Active Ingredients
Fipronil
Administration Routes
TopicalUnknownOralCutaneousOtherSubcutaneousTransdermalAuricular (Otic)
Species Affected
Dog 1,283
Cat 464
Unknown 5
Human 1
Most Affected Breeds
Domestic Shorthair 248
Retriever - Labrador 135
Crossbred Canine/dog 74
Domestic Longhair 70
Terrier - Yorkshire 57
Dog (unknown) 52
Shih Tzu 50
Shepherd Dog - German 49
Cat (unknown) 48
Retriever - Golden 48
Most Reported Reactions
Lack of efficacy (ectoparasite) - flea 455
Emesis 254
Lethargy (see also Central nervous system depression in 'Neurological') 220
Vomiting 201
Lack of efficacy - NOS 121
Diarrhoea 109
Panting 83
Lack of efficacy (flea) 72
Other abnormal test result NOS 69
Seizure NOS 62
Behavioural disorder NOS 62
Pruritus 61
Outcome Breakdown
Outcome Unknown
690 (39.5%)
Recovered/Normal
629 (36.0%)
Ongoing
294 (16.8%)
Recovered with Sequela
63 (3.6%)
Died
41 (2.3%)
Euthanized
30 (1.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.