Drug profile

The FDA adverse-event record for Ilunocitinib

1,815 FDA reports name Ilunocitinib, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#118 of 2,679
by report volume (all drugs)
1,815
adverse-event reports
5.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ilunocitinib ranks #118 of 2679 by total reports (1,815) and #741 of 1130 by death-coded share (5.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#118
This drug, reports of 2679
#741
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ilunocitinib has 1,815 reports now versus 1,416 in that prior snapshot: 399 more (28.2%).

Report change
+399
Death-coded reports
+27
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ilunocitinib changes

Signature read: 1,815 reports place Ilunocitinib in the upper third of FDA AER volume (#118 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,815
Total Reports
107
Deaths Reported
5.9%
Death-coded share of reports

Active Ingredients

Ilunocitinib

Administration Routes

OralUnknown

Species Affected

Dog 1,773
Unknown 37
Human 4
Cat 1

Most Affected Breeds

Retriever - Labrador 222
Dog (unknown) 157
Pit Bull 121
Retriever - Golden 99
Crossbred Canine/dog 90
Shepherd Dog - German 89
Bulldog - French 74
Shih Tzu 61
Bulldog - English 57
Chihuahua 44

Most Reported Reactions

Lack of efficacy - NOS 326
Lethargy (see also Central nervous system depression in Neurological) 232
Diarrhoea 200
Vomiting 175
Neutropenia 173
Decreased haematocrit 138
Elevated serum alkaline phosphatase (ALP) 123
Lymphopenia 114
Leucopenia NOS 102
Elevated alanine aminotransferase (ALT) 101
Other abnormal test result NOS 98
Anaemia NOS 91

Outcome Breakdown

Outcome Unknown
778 (43.7%)
Ongoing
572 (32.1%)
Recovered/Normal
324 (18.2%)
Euthanized
68 (3.8%)
Died
39 (2.2%)

Ilunocitinib: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Ilunocitinib, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (1,815 here).

Similar death-coded share

Nearest other drugs by death-coded share (5.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ilunocitinib (#118 of 2,679 by report volume); death-coded 5.9%. PlainBreed drug row · report volume stamp 1,815 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →