Drug profile

The FDA adverse-event record for Imidacloprid, Moxidectin

1,792 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid, Moxidectin. See the species affected, top reactions, and outcomes below.

1,792
adverse-event reports
4.1%
death-coded share
Dog
most-reported species
269
Depression - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,792
Total Reports
74
Deaths Reported
4.1%
Death Rate

Active Ingredients

Imidacloprid, Moxidectin

Administration Routes

TopicalUnknownOtherOralIntraocularOphthalmicNasalIntrauterineRespiratory (Inhalation)Subcutaneous

Species Affected

Dog 1,110
Cat 583
Unknown 48
Human 48
Guinea Pig 1
Rabbit 1
Other 1

Most Affected Breeds

Domestic (unspecified) 390
Crossbred Canine/dog 174
Retriever - Labrador 107
Dog (unknown) 103
Cat (unknown) 99
Unknown 98
Chihuahua 57
Terrier - Yorkshire 54
Shepherd Dog - German 46
Domestic Shorthair 43

Most Reported Reactions

Depression 269
Vomiting 249
Lack of efficacy (endoparasite) - heartworm 178
Hypersalivation 177
Anorexia 139
Behavioural disorder NOS 121
Ataxia 114
Hyperactivity 111
Application site alopecia 108
Accidental exposure 107
Trembling 106
Lack of efficacy (ectoparasite) - flea 104

Outcome Breakdown

Outcome Unknown
391 (60.2%)
Ongoing
119 (18.3%)
Recovered/Normal
66 (10.2%)
Died
62 (9.5%)
Euthanized
12 (1.8%)

Imidacloprid, Moxidectin Adverse Event Insights

1,792 reports name Imidacloprid, Moxidectin; 74 recorded a death outcome (4.1% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid, Moxidectin. Administration routes: Topical, Unknown, Other, Oral.

By species: Dog (1,110 reports), Cat (583 reports), Unknown (48 reports). By breed: Domestic (unspecified) (390), Crossbred Canine/dog (174), Retriever - Labrador (107).

Leading clinical signs: Depression (269), Vomiting (249), Lack of efficacy (endoparasite) - heartworm (178), Hypersalivation (177). Outcome, 650 coded reports: Outcome Unknown leads at 60.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.