Drug profile

The FDA adverse-event record for Imidacloprid, Moxidectin

1,797 FDA reports name Imidacloprid, Moxidectin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#119 of 2,679
by report volume (all drugs)
1,797
adverse-event reports
4.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imidacloprid, Moxidectin ranks #119 of 2679 by total reports (1,797) and #837 of 1130 by death-coded share (4.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#119
This drug, reports of 2679
#837
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imidacloprid, Moxidectin has 1,797 reports now versus 1,794 in that prior snapshot: 3 more (0.2%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imidacloprid, Moxidectin changes

Signature read: 1,797 reports place Imidacloprid, Moxidectin in the upper third of FDA AER volume (#119 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,797
Total Reports
74
Deaths Reported
4.1%
Death-coded share of reports

Active Ingredients

Imidacloprid, Moxidectin

Administration Routes

TopicalUnknownOtherOralIntraocularOphthalmicNasalIntrauterineRespiratory (Inhalation)Subcutaneous

Species Affected

Dog 1,113
Cat 585
Unknown 48
Human 48
Guinea Pig 1
Rabbit 1
Other 1

Most Affected Breeds

Domestic (unspecified) 390
Crossbred Canine/dog 174
Retriever - Labrador 108
Dog (unknown) 103
Cat (unknown) 99
Unknown 98
Chihuahua 57
Terrier - Yorkshire 54
Shepherd Dog - German 46
Domestic Shorthair 45

Most Reported Reactions

Depression 269
Vomiting 249
Lack of efficacy (endoparasite) - heartworm 181
Hypersalivation 177
Anorexia 139
Behavioural disorder NOS 121
Ataxia 114
Hyperactivity 111
Application site alopecia 108
Accidental exposure 107
Trembling 106
Lack of efficacy (ectoparasite) - flea 104

Outcome Breakdown

Outcome Unknown
391 (59.7%)
Ongoing
124 (18.9%)
Recovered/Normal
66 (10.1%)
Died
62 (9.5%)
Euthanized
12 (1.8%)

Imidacloprid, Moxidectin: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Imidacloprid, Moxidectin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (4.1% here), distinct from the volume row.

What to do with this drug

  • Compare Imidacloprid, Moxidectin's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imidacloprid, Moxidectin (#119 of 2,679 by report volume); death-coded 4.1%. PlainBreed drug row · report volume stamp 1,797 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →