Milbemycin Oxime & Lufenuron
538 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
538
Total Reports
22
Deaths Reported
410.0%
Death Rate
Active Ingredients
Milbemycin Oxime & Lufenuron
Administration Routes
OralUnknown
Species Affected
Dog 537
Cat 1
Most Affected Breeds
Retriever - Labrador 91
Retriever - Golden 33
Shepherd Dog - German 22
Beagle 20
Terrier - Bull - American Pit 19
Chihuahua 18
Shih Tzu 17
Shepherd Dog - Australian 12
Terrier - Yorkshire 12
Maltese 12
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 109
Vomiting 95
Lethargy (see also Central nervous system depression in 'Neurological') 81
Seizure NOS 56
Diarrhoea 41
Lack of efficacy - NOS 36
Tremor 34
INEFFECTIVE, HEARTWORM LARVAE 30
Anorexia 29
Other abnormal test result NOS 23
Elevated alanine aminotransferase (ALT) 23
Ataxia 19
Outcome Breakdown
Ongoing
353 (65.6%)
Recovered/Normal
100 (18.6%)
Outcome Unknown
63 (11.7%)
Died
12 (2.2%)
Euthanized
10 (1.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.