Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg
1,759 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,759
Total Reports
24
Deaths Reported
140.0%
Death Rate
Active Ingredients
Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg
Administration Routes
OralUnknownIntravenousTopical
Species Affected
Dog 1,675
Unknown 79
Human 3
Cat 2
Most Affected Breeds
Retriever - Labrador 477
Shepherd Dog - German 139
Crossbred Canine/dog 137
Retriever - Golden 117
Dog (unknown) 93
Unknown 82
Boxer (German Boxer) 62
American Pit Bull Terrier 55
Rottweiler 32
Mixed (Dog) 29
Most Reported Reactions
INEFFECTIVE, HEARTWORM LARVAE 584
Lack of efficacy - NOS 404
Vomiting 387
Lack of efficacy (endoparasite) - hookworm 246
INEFFECTIVE, ASCARIDS NOS 184
Diarrhoea 130
Lethargy (see also Central nervous system depression in 'Neurological') 110
Lack of efficacy (endoparasite) - tapeworm 98
Drug dose administration interval too long 77
Overdose 54
Uncoded sign 49
Drug dose omission 49
Outcome Breakdown
Outcome Unknown
1,053 (62.5%)
Recovered/Normal
523 (31.0%)
Ongoing
50 (3.0%)
Recovered with Sequela
35 (2.1%)
Died
13 (0.8%)
Euthanized
11 (0.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.