Drug profile

The FDA adverse-event record for Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg

1,759 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg. See the species affected, top reactions, and outcomes below.

1,759
adverse-event reports
1.4%
death-coded share
Dog
most-reported species
584
INEFFECTIVE, HEARTWORM LARVAE - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,759
Total Reports
24
Deaths Reported
1.4%
Death Rate

Active Ingredients

Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg

Administration Routes

OralUnknownIntravenousTopical

Species Affected

Dog 1,675
Unknown 79
Human 3
Cat 2

Most Affected Breeds

Retriever - Labrador 477
Shepherd Dog - German 139
Crossbred Canine/dog 137
Retriever - Golden 117
Dog (unknown) 93
Unknown 82
Boxer (German Boxer) 62
American Pit Bull Terrier 55
Rottweiler 32
Mixed (Dog) 29

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 584
Lack of efficacy - NOS 404
Vomiting 387
Lack of efficacy (endoparasite) - hookworm 246
INEFFECTIVE, ASCARIDS NOS 184
Diarrhoea 130
Lethargy (see also Central nervous system depression in 'Neurological') 110
Lack of efficacy (endoparasite) - tapeworm 98
Drug dose administration interval too long 77
Overdose 54
Uncoded sign 49
Drug dose omission 49

Outcome Breakdown

Outcome Unknown
1,053 (62.5%)
Recovered/Normal
523 (31.0%)
Ongoing
50 (3.0%)
Recovered with Sequela
35 (2.1%)
Died
13 (0.8%)
Euthanized
11 (0.7%)

Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg Adverse Event Insights

1,759 reports name Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg; 24 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg. Administration routes: Oral, Unknown, Intravenous, Topical.

By species: Dog (1,675 reports), Unknown (79 reports), Human (3 reports). By breed: Retriever - Labrador (477), Shepherd Dog - German (139), Crossbred Canine/dog (137).

Leading clinical signs: INEFFECTIVE, HEARTWORM LARVAE (584), Lack of efficacy - NOS (404), Vomiting (387), Lack of efficacy (endoparasite) - hookworm (246). Outcome, 1,685 coded reports: Outcome Unknown leads at 62.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.