Drug profile

The FDA adverse-event record for Desoxycorticosterone Pivalate

1,745 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Desoxycorticosterone Pivalate. See the species affected, top reactions, and outcomes below.

1,745
adverse-event reports
7.4%
death-coded share
Dog
most-reported species
247
Immediate pain upon injection - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,745
Total Reports
129
Deaths Reported
7.4%
Death Rate

Active Ingredients

Desoxycorticosterone Pivalate

Administration Routes

SubcutaneousIntramuscularUnknownParenteralIntravenousOralOtherOphthalmicCutaneous

Species Affected

Dog 1,573
Unknown 152
Cat 10
Monkey 7
Human 2
Goat 1

Most Affected Breeds

Retriever - Labrador 204
Unknown 155
Crossbred Canine/dog 107
Dog (unknown) 79
Poodle - Standard 78
Chihuahua 51
Beagle 48
Deutsche Dogge, Great Dane 39
Retriever - Golden 39
Pointing Dog - German Short-haired 39

Most Reported Reactions

Immediate pain upon injection 247
Lethargy (see also Central nervous system depression in 'Neurological') 228
Vomiting 204
Polyuria 196
Polydipsia 192
Other abnormal test result NOS 160
High sodium-potassium ratio (Na:K ratio) 159
Diarrhoea 156
Lack of efficacy - NOS 131
Anorexia 124
Vocalisation 118
Weight gain 83

Outcome Breakdown

Recovered/Normal
584 (42.1%)
Outcome Unknown
448 (32.3%)
Ongoing
219 (15.8%)
Died
67 (4.8%)
Euthanized
62 (4.5%)
Recovered with Sequela
8 (0.6%)

Desoxycorticosterone Pivalate Adverse Event Insights

1,745 reports name Desoxycorticosterone Pivalate; 129 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). Active ingredient: Desoxycorticosterone Pivalate. Administration routes: Subcutaneous, Intramuscular, Unknown, Parenteral.

By species: Dog (1,573 reports), Unknown (152 reports), Cat (10 reports). By breed: Retriever - Labrador (204), Unknown (155), Crossbred Canine/dog (107).

Leading clinical signs: Immediate pain upon injection (247), Lethargy (see also Central nervous system depression in 'Neurological') (228), Vomiting (204), Polyuria (196). Outcome, 1,388 coded reports: Recovered/Normal leads at 42.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.