Reaction profile

The FDA adverse-event record for vulvitis

68 FDA adverse-event reports reference vulvitis (VeDDRA 823). See the species, breeds, and drugs most associated with it below.

68
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species
Estriol
most-associated drug
Verify with FDA CVM →
68
Total Reports
5
Deaths
7.4%
Death Rate

Species Most Affected

Dog 60
Cattle 4
Cat 2
Pig 2

Breeds Most Affected

Crossbred Canine/dog 6
Shepherd Dog - German 4
Terrier - Yorkshire 4
Pit Bull 3
Retriever - Golden 3
Sheepdog - Shetland 2
Spitz - German Pomeranian 2
Dachshund (unspecified) 2
Aberdeen Angus 2
Boxer (German Boxer) 2

Associated Drugs

Estriol 17
Carprofen 4
Milbemycin Oxime + Spinosad 4
Oclacitinib Maleate 4
Imidacloprid + Moxidectin 3
Estriol Tablets 3
Glycosaminoglycan Polysulfate 2
Cefpodoxime Proxetil 2
Dinoprost Tromethamine 2
Spinosad 2
Altrenogest 2
Sarolaner 2
Pyrantel Pamoate;Sarolaner 2
Prescription Diet (Unspecified) 2
Amoxicillin, Clavulanate 1
Dirlotapide 1
Cyclosporine 1
Monensin 1
Maropitant 1
Deracoxib 1

Vulvitis Reaction Insights

68 reports name Vulvitis; 5 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). VeDDRA code: 823.

By species: Dog (60 reports), Cattle (4 reports), Cat (2 reports). By breed: Crossbred Canine/dog (6), Shepherd Dog - German (4), Terrier - Yorkshire (4).

Most co-reported drugs: Estriol (17 reports), Carprofen (4 reports), Milbemycin Oxime + Spinosad (4 reports), Oclacitinib Maleate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.