Reaction profile

The FDA adverse-event record for hyporeflexia

70 FDA adverse-event reports reference hyporeflexia (VeDDRA 1220). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1576 of 2,481
by report volume (all reactions)
70
reports citing this reaction
41.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyporeflexia has 70 reports now versus 69 in that prior snapshot: 1 more (1.4%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyporeflexia changes

FDA AER · VeDDRA plate

Code 1220 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 70 reports
  • DEATH-HOT 41.4%
  • MID-PACK #1576/2481
  • PHOTO-FINISH Application site warm…
  • SPECIES-DOG Dog · 60
  • DRUG-LEAD Carprofen · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site warmth (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Hyporeflexia

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site warm… · near70Digestive tract hyper… · near70Hyporeflexia · this reaction70Musculoskeletal neopl… · near70Saline slide agglutin… · near70Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyporeflexia

Hyporeflexia: high death-coded share in the FDA AER plate

Signature read: Hyporeflexia's 41.4% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 29 of 70 reports (41.4% of named reports). Nearest volume peer: Application site warmth (±0 reports). Lead species Dog (60). Lead co-reported drug Carprofen (7).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 60
Cat 8
Other Reptiles 1
Horse 1

Breeds Most Affected

Domestic Shorthair 5
Retriever - Labrador 5
Retriever - Golden 4
Dachshund (unspecified) 3
Crossbred Canine/dog 3
Pit Bull 3
Terrier - Jack Russell 2
Maltese 2
Shih Tzu 2
Siberian Husky 2

Associated Drugs

Carprofen 7
Milbemycin Oxime + Spinosad 6
Maropitant Citrate 6
Butorphanol 5
Afoxolaner 5
Bedinvetmab 5
Enrofloxacin 4
Ketamine 4
Acepromazine 4
Melarsomine Dihydrochloride Injection 4
Dexmedetomidine Hydrochloride 4
Isoflurane 4
Fluralaner 13.64% 12-Week Chew 4
Meloxicam 3
Prednisone 3
Capromorelin 3
Epinephrine 3
Famotidine 3
Diphenhydramine 3
Praziquantel 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hyporeflexia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (41.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyporeflexia (#1576 of 2,481 by report volume); death-coded 41.4%. PlainBreed reaction plate · death-coded share stamp 41.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →