Reaction profile

The FDA adverse-event record for hyporeflexia

68 FDA adverse-event reports reference hyporeflexia (VeDDRA 1220). See the species, breeds, and drugs most associated with it below.

68
reports citing this reaction
42.6%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
68
Total Reports
29
Deaths
42.6%
Death Rate

Species Most Affected

Dog 58
Cat 8
Other Reptiles 1
Horse 1

Breeds Most Affected

Domestic Shorthair 5
Retriever - Labrador 5
Dachshund (unspecified) 3
Crossbred Canine/dog 3
Retriever - Golden 3
Pit Bull 3
Terrier - Jack Russell 2
Maltese 2
Shih Tzu 2
Siberian Husky 2

Associated Drugs

Carprofen 7
Milbemycin Oxime + Spinosad 6
Maropitant Citrate 6
Butorphanol 5
Afoxolaner 5
Enrofloxacin 4
Ketamine 4
Acepromazine 4
Melarsomine Dihydrochloride Injection 4
Dexmedetomidine Hydrochloride 4
Isoflurane 4
Fluralaner 13.64% 12-Week Chew 4
Meloxicam 3
Prednisone 3
Capromorelin 3
Epinephrine 3
Bedinvetmab 3
Famotidine 3
Diphenhydramine 3
Spinosad 2

Hyporeflexia Reaction Insights

68 reports name Hyporeflexia; 29 recorded a death outcome (42.6% of reported events, not a population-level mortality rate). VeDDRA code: 1220.

By species: Dog (58 reports), Cat (8 reports), Other Reptiles (1 reports). By breed: Domestic Shorthair (5), Retriever - Labrador (5), Dachshund (unspecified) (3).

Most co-reported drugs: Carprofen (7 reports), Milbemycin Oxime + Spinosad (6 reports), Maropitant Citrate (6 reports), Butorphanol (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.