Reaction profile

The FDA adverse-event record for abnormal oestrus nos

56 FDA reports name abnormal oestrus nos, a lower-volume reaction in the CVM extract (VeDDRA 1162). Plate stamps and neighbourhood peers follow.

#1681 of 2,481
by report volume (all reactions)
56
reports citing this reaction
7.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal oestrus NOS has 56 reports now versus 56 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal oestrus NOS changes

FDA AER · VeDDRA plate

Code 1162 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 56 reports
  • DEATH-PAR 7.1%
  • MID-PACK #1681/2481
  • PHOTO-FINISH Abdominal oedema
  • SPECIES-DOG Dog · 36
  • DRUG-LEAD Milbemycin Oxime… · 11
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal oedema (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Abnormal oestrus NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abdominal oedema · near56Abnormal oestrus NOS · this …56High leg gait · near56Indigestion · near56Pinnal haemorrhage · near56Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal oestrus NOS

Abnormal oestrus NOS: low death-coded share in the FDA AER plate

Signature read: 4 death-coded reports is a thin tail count for Abnormal oestrus NOS in the CVM extract. Report volume is lower-third scale: 56 named reports in the openFDA extract. Death-coded share is lower-third: 4 of 56 reports (7.1% of named reports). Nearest volume peer: Abdominal oedema (±0 reports). Lead species Dog (36). Lead co-reported drug Milbemycin Oxime + Spinosad (11).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 36
Cattle 14
Horse 3
Sheep 1
Pig 1
Cat 1

Breeds Most Affected

Dog (unknown) 8
Holstein-Friesian also known as Holstein 5
Retriever - Labrador 4
Aberdeen Angus 3
Spaniel - Cocker American 2
Terrier - Yorkshire 2
Shepherd Dog - German 2
Crossbred Canine/dog 2
Doberman Pinscher 2
Cattle (unknown) 2

Associated Drugs

Milbemycin Oxime + Spinosad 11
Spinosad 7
Estradiol 5
Estriol Tablets 5
Monensin Sodium 3
Estradiol Benzoate; Trenbolone Acetate 3
Cyclosporine A 2
Vaccines (Unknown) 2
Estriol 2
Altrenogest Oily Solution 2
Melengestrol Acetate 2
Fluralaner Chew Tablets 2
Moxidectin 2
Progesterone 1
Pimobendan 1
Tacrolimus 1
Prednisolone; Trimeprazine Tartrate 1
Sometribove 1
Afoxolaner 1
Tiamulin Hydrogen Fumarate 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal oestrus NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (56 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal oestrus NOS (#1681 of 2,481 by report volume); death-coded 7.1%. PlainBreed reaction plate · death-coded report count stamp 4 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →