Reaction profile

The FDA adverse-event record for digestive tract hypermotility

69 FDA adverse-event reports reference digestive tract hypermotility (VeDDRA 1889). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
8.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
69
Total Reports
6
Deaths
8.7%
Death Rate

Species Most Affected

Dog 56
Horse 9
Cat 3
Human 1

Breeds Most Affected

Crossbred Canine/dog 10
Retriever - Labrador 6
Spaniel - Springer (unspecified) 3
Domestic (unspecified) 2
Arab 2
Dog (unknown) 2
Siberian Husky 2
Poodle (unspecified) 2
Unknown 2
Collie - Border 2

Associated Drugs

Carprofen 6
Firocoxib 227 Mg Chewable 5
Milbemycin Oxime + Spinosad 5
Grapiprant 5
Fenbendazole 4
Fluralaner Chew Tablets 4
Fluralaner 13.64% 12-Week Chew 4
Maropitant 3
Moxidectin 3
Spinosad 3
Ivermectin 3
Trilostane 3
Deracoxib 2
Meloxicam 2
Pyrantel Pamoate 2
Imidacloprid + Moxidectin 2
Oxybendazole 2
Milbemycin Oxime + Praziquantel 2
Milbemycin/Lufenuron/Pzq Chew 2
Cefovecin Sodium 1

Digestive tract hypermotility Reaction Insights

69 reports name Digestive tract hypermotility; 6 recorded a death outcome (8.7% of reported events, not a population-level mortality rate). VeDDRA code: 1889.

By species: Dog (56 reports), Horse (9 reports), Cat (3 reports). By breed: Crossbred Canine/dog (10), Retriever - Labrador (6), Spaniel - Springer (unspecified) (3).

Most co-reported drugs: Carprofen (6 reports), Firocoxib 227 Mg Chewable (5 reports), Milbemycin Oxime + Spinosad (5 reports), Grapiprant (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.