Reaction profile

The FDA adverse-event record for tremor

7,718 FDA adverse-event reports reference tremor (VeDDRA 1852). See the species, breeds, and drugs most associated with it below.

7,718
reports citing this reaction
7.0%
death-coded share
Dog
most-affected species
Sarolaner
most-associated drug
Verify with FDA CVM →
7,718
Total Reports
539
Deaths
7.0%
Death Rate

Species Most Affected

Dog 6,761
Cat 891
Horse 22
Human 12
Cattle 10
Pig 6
Rabbit 3
Sheep 2
Guinea Pig 2
Unknown 2

Breeds Most Affected

Retriever - Labrador 572
Domestic Shorthair 566
Terrier - Yorkshire 481
Crossbred Canine/dog 461
Chihuahua 384
Retriever - Golden 295
Shih Tzu 258
Dog (unknown) 241
Maltese 205
Terrier (unspecified) 175

Associated Drugs

Sarolaner 1,373
Milbemycin Oxime + Spinosad 1,265
Pyrantel Pamoate;Sarolaner 968
Afoxolaner 668
Fluralaner 13.64% 12-Week Chew 327
Ivermectin + Pyrantel As Pamoate Salt 266
Fluralaner Chew Tablets 239
Spinosad 235
Maropitant Citrate 215
Selamectin 211
Ivermectin 200
Milbemycin Oxime + Praziquantel 185
Oclacitinib Maleate 178
Imidacloprid + Moxidectin 173
Moxidectin 165
Trilostane 159
Bedinvetmab 156
Lotilaner 147
Gabapentin 140
Selamectin;Sarolaner 131

Tremor Reaction Insights

7,718 reports name Tremor; 539 recorded a death outcome (7.0% of reported events, not a population-level mortality rate). VeDDRA code: 1852.

By species: Dog (6,761 reports), Cat (891 reports), Horse (22 reports). By breed: Retriever - Labrador (572), Domestic Shorthair (566), Terrier - Yorkshire (481).

Most co-reported drugs: Sarolaner (1,373 reports), Milbemycin Oxime + Spinosad (1,265 reports), Pyrantel Pamoate;Sarolaner (968 reports), Afoxolaner (668 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.