Reaction profile

The FDA adverse-event record for high leg gait

51 FDA adverse-event reports reference high leg gait (VeDDRA 661). See the species, breeds, and drugs most associated with it below.

51
reports citing this reaction
7.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
51
Total Reports
4
Deaths
7.8%
Death Rate

Species Most Affected

Dog 44
Cat 4
Horse 2
Unknown 1

Breeds Most Affected

Retriever - Golden 5
Retriever - Labrador 5
Chihuahua 4
Catahoula Leopard Dog 3
Crossbred Canine/dog 3
Domestic Shorthair 3
Poodle - Standard 2
Poodle - Miniature 2
Poodle - Toy 1
Unknown 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Spinosad 4
Trilostane 4
Fluralaner Chew Tablets 4
Sarolaner 4
Pyrantel Pamoate;Sarolaner 4
Moxidectin 3
Carprofen 3
Bedinvetmab 3
Imidacloprid + Moxidectin 2
Heartworm Prevention (Unknown) 2
Selamectin 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 2
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 2
Cefpodoxime Proxetil 2
Cyclosporine 2
Cephalexin 2
Ivermectin + Praziquantel + Pyrantel Pamoate 2
Fluralaner 5.46% 1-Month Chew 2
Fluralaner 13.64% 12-Week Chew 2

High leg gait Reaction Insights

51 reports name High leg gait; 4 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). VeDDRA code: 661.

By species: Dog (44 reports), Cat (4 reports), Horse (2 reports). By breed: Retriever - Golden (5), Retriever - Labrador (5), Chihuahua (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Spinosad (4 reports), Trilostane (4 reports), Fluralaner Chew Tablets (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.